[Myocardial contractile and calcium transport function after severe burn injury].

Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns Pub Date : 1998-05-01

J Yang, Z Yang, F Chen

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Abstract

Objective: This study examined the changes in myocardial calcium transport function and what roles it played in cardiac dysfunction after severe burn injury.

Methods: Contraction relaxation properties of the left ventricule (LV) were studied in isolated heart preparations of Wistar rat 3, 8, 24 hours after 30% TBSA full thickness burn. Sarcoplasmic reticulum (SR) calcium transport function was measured by millipore filtration technique.

Results: The maximal rates of LV pressure elevation (+ dp/ dtmax) and depression (-dp/dtmax) in burn group were significantly lower than that in control group (P < 0.01). The initial rate and capacity of calcium uptake by SR decreased markedly in burn group than in control group (P < 0.01). In addition, calcium dependent ATPase activity and coupling ratio of SR were also markedly depressed.

Conclusion: SR calcium transport function depression was closely related to cardiac contractile dysfunction, and the former is one of the important mechanism for cardiac contractile dysfunction after severe burn injury.

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[严重烧伤后心肌收缩和钙转运功能]。

目的:探讨严重烧伤后心肌钙转运功能的变化及其在心功能障碍中的作用。方法:研究30% TBSA全层烧伤后3、8、24小时Wistar大鼠离体心脏制剂左心室收缩舒张特性。采用毫孔过滤技术测定肌浆网钙转运功能。结果:烧伤组患者最大左室压升高率(+ dp/dtmax)和最大左室压降低率(-dp/dtmax)均显著低于对照组(P < 0.01)。烧伤组大鼠SR初始钙吸收速率和钙吸收容量显著低于对照组(P < 0.01)。此外，钙依赖性atp酶活性和SR偶联率也明显降低。结论:SR钙转运功能下降与心肌收缩功能障碍密切相关，前者是严重烧伤后心肌收缩功能障碍的重要机制之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns

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