[The effect of tangential excision on the local IL-8 release and wound inflammatory response in deep-partial thickness burn].

Abstract

Objective: The aim of this study is to investigate the effect of tangential excision on the local IL-8 release and wound inflammatory response.

Methods: The tissue specimens, which were taken from 7 patients with deep partial thickness burn before and after operation, were both cultured and histopathologically examined. The level of IL-8 in the culture medium was assayed, meanwhile local inflammatory response of tissue samples was evaluated.

Results: The result showed that the level of IL-8 is much lower in the postoperation wounds, while in the non-operation wounds the neutrophil infiltration was marked, with enlargement in necrotic area and disappearance of skin appendages.

Conclusion: The findings suggested that tangential excision could reduce the local production of IL-8 and decrease local inflammatory response, which is helpful to prevent the progressive necrosis of burn wound.