{"title":"Apoptosis in acute pancreatitis.","authors":"Z J He, I Podkletnova, H Alho, J Sand, I Nordback","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Apoptosis may be involved in the mechanism of acinar cell injury in acute experimental pancreatitis.</p><p><strong>Aim: </strong>This study was to investigate whether apoptosis also is involved in human acute pancreatitis.</p><p><strong>Method: </strong>A needle biopsy pancreatic specimen was obtained from a patient with acute oedematous pancreatitis. The specimen was stained with In Situ Cell Death Detection Kit. Similar specimen from a patient undergoing pancreatoduodenectomy for bile duct cancer served as a control.</p><p><strong>Results: </strong>Extended acinar cell apoptosis was found in the pancreatitis specimen. No single apoptotic cell was found in the control pancreas.</p><p><strong>Conclusion: </strong>Apoptosis probably is involved not only in acute experimental pancreatitis but also in human acute oedematous pancreatitis. The induction and role of apoptosis in pancreatis is discussed based on literature.</p>","PeriodicalId":75495,"journal":{"name":"Annales chirurgiae et gynaecologiae","volume":"89 1","pages":"65-7"},"PeriodicalIF":0.0000,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales chirurgiae et gynaecologiae","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Apoptosis may be involved in the mechanism of acinar cell injury in acute experimental pancreatitis.
Aim: This study was to investigate whether apoptosis also is involved in human acute pancreatitis.
Method: A needle biopsy pancreatic specimen was obtained from a patient with acute oedematous pancreatitis. The specimen was stained with In Situ Cell Death Detection Kit. Similar specimen from a patient undergoing pancreatoduodenectomy for bile duct cancer served as a control.
Results: Extended acinar cell apoptosis was found in the pancreatitis specimen. No single apoptotic cell was found in the control pancreas.
Conclusion: Apoptosis probably is involved not only in acute experimental pancreatitis but also in human acute oedematous pancreatitis. The induction and role of apoptosis in pancreatis is discussed based on literature.
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