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Pancreatic Lymphoma 胰腺淋巴瘤
Pub Date : 2020-02-07 DOI: 10.32388/ovtctj
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引用次数: 2
Toe-to-Hand Transfer Toe-to-Hand转移
Pub Date : 2019-06-13 DOI: 10.1201/9780429265822-30
Kauko A. Solonen
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引用次数: 14
Laparoscopic laser cholecystectomy. 腹腔镜激光胆囊切除术。
Pub Date : 2010-09-20 DOI: 10.1089/LMS.1989.7.1.38
E. Reddick, D. Olsen, J. Daniell, W. Saye, B. McKernan, W. Miller, Michael Hoback
The standard treatment of cholelithiasis in the United States is surgical removal of the gallbladder, but this treatment often has a major economic impact on the patient: major surgery, lengthy hospitalization, and several weeks' absence from work. Because of this economic factor, there has been a movement toward non-invasive methods, but they, too, have their drawbacks: long-term medical therapy; a high risk of stone recurrence because the diseased gallbladder is still in place. We therefore developed a means of performing a cholecystectomy through a laparoscope using laser technology, the results of which are compared here with the results in a series of “mini-lap” cholecystectomies that we also performed during the same time period.
在美国,胆石症的标准治疗方法是手术切除胆囊,但这种治疗通常对患者有重大的经济影响:大手术、长时间住院和几周缺勤。由于这一经济因素,已经出现了一种非侵入性方法的运动,但它们也有其缺点:长期药物治疗;结石复发的高风险,因为病变的胆囊仍在原位。因此,我们开发了一种通过腹腔镜使用激光技术进行胆囊切除术的方法,其结果与我们在同一时期进行的一系列“迷你”胆囊切除术的结果进行了比较。
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引用次数: 34
Surgical Treatment of Colorectal Liver Metastases 结直肠肝转移瘤的外科治疗
Pub Date : 2010-01-01 DOI: 10.1007/978-88-470-1809-9
L. Capussotti, Alessandro Ferrero, A. Muratore, Dario Ribero, Luca Viganò
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引用次数: 6
Blood, sweat and tears. 热血、汗水和泪水。
Pub Date : 2001-01-01 DOI: 10.1093/nq/187.8.174e
A. Leppäniemi
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引用次数: 0
The treatment of pancreatic cancer. 胰腺癌的治疗。
Pub Date : 2000-01-01
C J Yeo, J L Cameron
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引用次数: 0
Continuous medical education. 继续医学教育。
Pub Date : 2000-01-01
P J Roberts
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引用次数: 0
Management and outcome of traumatic aortic injuries. 外伤性主动脉损伤的处理和预后。
Pub Date : 2000-01-01
M Jousi, A Leppäniemi

Background and aims: Aortic injuries are rare and associated with high early mortality challenging the surgical services both from a technical as well as organisational point of view, especially in countries with low incidence of trauma. A Finnish experience in the management of aortic injuries is reported with special emphasis on outcome after early involvement of cardiothoracic surgeons.

Material and methods: Retrospective analysis of hospital records identified 36 consecutive patients with aortic injuries arriving alive to the hospital during a 32-year period of 1967-98.

Results: Of the 19 thoracic aortic injuries, 17 (89%) were caused by blunt trauma, 8 (42%) of the patients arrived in shock, 7 (37%) died before repair could be attempted, 11 (58%) underwent repair with prosthesis and one (5%) with sutures, with an overall mortality rate of 9/19 (47%). Of the 17 patients with abdominal aortic injuries (15 penetrating), 13 (76%) arrived in shock, 3 (18%) died before repair, 13 (76%) were repaired with sutures and one (6%) with prosthesis, with an overall mortality rate of 8/17 (47%). Fourteen (82%) of the 17 non-survivors died within 24 hours from the injury, 13 from exsanguination and one from associated brain injury.

Conclusions: Abdominal aortic injuries are usually penetrating, diagnosed intraoperatively and amenable to suture repair with good results indicating that stable and unstable patients with potential aortic injuries after penetrating abdominal trauma can safely be managed in hospitals with experienced general surgeons on call. In contrast, stable patients with suspected thoracic aortic injuries could benefit from early transfer to a hospital with cardiothoracic surgical facilities and personnel.

背景和目的:主动脉损伤是罕见的,并且与高早期死亡率相关,从技术和组织的角度对手术服务提出了挑战,特别是在创伤发生率低的国家。芬兰在主动脉损伤的管理经验报告,特别强调早期介入心胸外科手术后的结果。材料和方法:回顾性分析1967- 1998年32年间36例连续存活至医院的主动脉损伤患者的医院记录。结果:19例胸主动脉损伤中,钝性损伤17例(89%),休克8例(42%),未尝试修复死亡7例(37%),假体修复11例(58%),缝合修复1例(5%),总死亡率为9/19(47%)。17例腹主动脉损伤患者(15例穿透性)中,13例(76%)休克,3例(18%)在修复前死亡,缝合修复13例(76%),假体修复1例(6%),总死亡率为8/17(47%)。17名非幸存者中有14人(82%)在24小时内死亡,13人死于失血过多,1人死于相关的脑损伤。结论:腹主动脉损伤通常是穿透性的,术中诊断并可进行缝合修复,结果良好,表明在有经验丰富的普通外科医生随叫随到的医院中,稳定和不稳定的潜在腹主动脉损伤患者都可以安全处理。相比之下,病情稳定的疑似胸主动脉损伤患者可以及早转移到有心胸外科设施和人员的医院。
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引用次数: 0
Adenovirus-mediated gene transfer into an experimental pancreatic tumour. 腺病毒介导的基因转移到实验性胰腺肿瘤。
Pub Date : 2000-01-01
K Mäkinen, S Loimas, V M Kosma, J Wahlfors, S Ylä-Herttuala, E Alhava, J Jänne

Background and aims: Gene therapy has been suggested as a novel approach against pancreatic cancer, a disease with a grim prognosis with current modes of therapy. Despite recent advances in in vitro and experimental in vivo studies, there is no data available concerning gene transfer efficiency in intrapancreatic tumours in immunocompetent animal models.

Material and methods: In in vitro studies rat pancreatic carcinoma cells (DSL-6A/C1) were transduced with replication-deficient adenovirus carrying Escherichia Coli beta-galactosidase (lacZ) gene. Gene transfer efficacy was assessed at different multiplicities of infection (MOIs). Pancreatic tumours were induced by inoculating cultured DSL-6A/C1 cancer cells into Lewis rat pancreases. Established tumours were transduced and three days post-transduction, pancreatic tumours as well as other intra-abdominal organs were harvested and processed for histological analyses, including staining for marker gene expression.

Results and conclusions: In vitro assays showed that DSL-6A/C1 cells were transduced efficiently, even at low MOIs. In vivo gene transfer was successful in all animals, and all pancreatic samples showed reporter gene expression. Positive cells were detected in the peritumoural areas as well as to a lesser extent within the tumours. The transgene activity was not evenly distributed and the gene transfer efficiency varied from a few detectable blue cells to 11% per field. Our studies demonstrated safe in vivo gene transfer into intrapancreatic tumours, suggesting that pancreatic tumours are potential targets for in vivo delivery of therapeutic genes.

背景与目的:基因治疗已被认为是治疗胰腺癌的一种新方法,胰腺癌是一种预后不佳的疾病。尽管最近在体外和体内实验研究方面取得了进展,但在免疫能力强的动物模型中,没有关于胰腺内肿瘤基因转移效率的数据。材料和方法:用携带大肠杆菌β -半乳糖苷酶(lacZ)基因的复制缺陷腺病毒转染大鼠胰腺癌细胞(DSL-6A/C1)进行体外实验。在不同感染多重度(MOIs)下评估基因转移效果。将培养的DSL-6A/C1癌细胞接种于Lewis大鼠胰腺,诱导胰腺肿瘤发生。转导已建立的肿瘤,转导三天后,胰腺肿瘤和其他腹腔内器官被切除并进行组织学分析,包括标记基因表达染色。结果和结论:体外实验表明,即使在低moi条件下,DSL-6A/C1细胞也能有效转导。所有动物体内基因转移均成功,所有胰腺样本均显示报告基因表达。阳性细胞在肿瘤周围区域检测到,肿瘤内也有较小程度的阳性细胞。转基因活性分布不均匀,基因转移效率从几个可检测到的蓝色细胞到11%不等。我们的研究表明,体内基因转移到胰腺内肿瘤是安全的,这表明胰腺肿瘤是体内传递治疗基因的潜在靶点。
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引用次数: 0
Abdominal vascular injuries. The trauma surgeon's challenge. 腹部血管损伤。创伤外科医生的挑战。
Pub Date : 2000-01-01
J A Asensio, W Forno, E Gambaro, D Steinberg, K J Tsai, V Rowe, I Navarro Nuño, A Leppäniemi, D Demetriades
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引用次数: 0
期刊
Annales chirurgiae et gynaecologiae
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