Susanna Cotecchia , Olivier Rossier , Francesca Fanelli , Amedeo Leonardi , Pier G De Benedetti
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引用次数: 14
Abstract
In this chapter we summarize some aspects of the structure-functional relationship of the α1a and α1b-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor. Molecular modeling of the α1a and α1b-adrenergic receptor subtypes and computational simulation of receptor dynamics were useful to interpret the experimental findings derived from site directed mutagenesis studies.
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