{"title":"Sertraline inhibits the contractile responses to noradrenaline, KCI and electrical field stimulation of rat isolated vas deferens","authors":"N. I. Kalyoncu, R. Ozyavuz, S. Karaoglu","doi":"10.1111/j.1365-2680.1999.tb00010.x","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p><b>1</b> The aim of this study was to investigate the effect of sertraline, a selective serotonin re-uptake inhibitor, on contractile responses to noradrenaline (NA), KCI, serotonin (5-HT) and electrical field stimulation of rat isolated vas deferens.</p>\n <p><b>2</b> Pre-treatment with 10<sup>-4</sup> M sertraline showed inhibitory effects on responses to NA, KCI, 5-HT and electrical field stimulation, while pre-treatment with 10 <sup>-6</sup> and 10<sup>-5</sup> M sertraline caused potentiation of responses to NA (10<sup>-7</sup> and 10<sup>-6</sup> M).</p>\n <p><b>3</b> A voltage-dependent calcium channel activator, Bay K 8644, restored the inhibited responses when sertraline was washed out of the organ bath, although restoration could not be seen when sertraline was not removed.</p>\n <p><b>4</b> The inhibition of the contractile responses by sertraline pre-treatment may be via a mechanism through calcium channels which is additional to the selective serotonin re-uptake inhibitory effect of sertraline.</p>\n </div>","PeriodicalId":100151,"journal":{"name":"Autonomic and Autacoid Pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2009-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2680.1999.tb00010.x","citationCount":"28","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Autonomic and Autacoid Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2680.1999.tb00010.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 28
Abstract
1 The aim of this study was to investigate the effect of sertraline, a selective serotonin re-uptake inhibitor, on contractile responses to noradrenaline (NA), KCI, serotonin (5-HT) and electrical field stimulation of rat isolated vas deferens.
2 Pre-treatment with 10-4 M sertraline showed inhibitory effects on responses to NA, KCI, 5-HT and electrical field stimulation, while pre-treatment with 10 -6 and 10-5 M sertraline caused potentiation of responses to NA (10-7 and 10-6 M).
3 A voltage-dependent calcium channel activator, Bay K 8644, restored the inhibited responses when sertraline was washed out of the organ bath, although restoration could not be seen when sertraline was not removed.
4 The inhibition of the contractile responses by sertraline pre-treatment may be via a mechanism through calcium channels which is additional to the selective serotonin re-uptake inhibitory effect of sertraline.