Modification of cardiovascular responses to spinal GABAB receptor stimulation by cAMP and by KATP channel blockade in anaesthetized rats

Autonomic and Autacoid Pharmacology Pub Date : 2009-01-09 DOI:10.1111/j.1365-2680.1999.tb00007.x

H. C. Koh, I. C. Shin, J. H. Ha, D. J. Paik, J. S. Kang, C H. Lee

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引用次数: 2

Abstract

1 Intrathecal (i.t.) injection of baclofen (30, 60 and 100 nmol), a GABA_B receptor agonist, produced a dose-dependent decrease in blood pressure (BP) and heart rate (HR).

2 Pretreatment with 5-aminovaleric acid (50 nmol), a GABA_B receptor antagonist, blocked the depressor and bradycardic effects of baclofen (100 nmol).

3 Pretreatment with 8-bromo-cAMP (10 nmol), a cAMP analogue, attenuated the depressor and bradycardic effects of baclofen (100 nmol), but not with 8-bromo-cGMP (10 nmol), a cGMP analogue.

4 In addition, pretreatment with glipizide (20 nmol), an ATP-sensitive K⁺ channel (K_ATP) blocker, attenuated the depressor and bradycardic effects of baclofen (100 nmol).

5 These results suggest that GABA_B receptors in the spinal cord have an inhibitory role in the central cardiovascular regulation and that these depressive and bradycardic actions are modified by cAMP and by K_ATP channel blockade.

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cAMP和KATP通道阻断对麻醉大鼠脊髓GABAB受体刺激后心血管反应的影响

鞘内注射巴氯芬(30,60和100 nmol)，一种GABAB受体激动剂，产生剂量依赖性的血压(BP)和心率(HR)降低。2 . GABAB受体拮抗剂5-氨基戊酸(50 nmol)预处理可阻断巴氯芬(100 nmol)的降压和心动过缓作用。3预处理8-溴-cAMP (10 nmol)， cAMP类似物，可以减弱巴氯芬(100 nmol)的抑制作用和心动过缓作用，但8-溴-cGMP (10 nmol)， cGMP类似物不能。4此外，格列吡嗪(20 nmol)预处理，一种atp敏感的K+通道(KATP)阻滞剂，减弱巴氯芬(100 nmol)的抑制作用和心动过缓作用。这些结果表明，脊髓中的GABAB受体在中枢心血管调节中具有抑制作用，这些抑制和心动过缓的作用被cAMP和KATP通道阻断所改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Autonomic and Autacoid Pharmacology

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