Circadian rhythm of phagocytosis in mice.

Abstract

There has been reported, in some diurnal or equivocal species (man, respectively guinea pig), a circadian rhythm of the phagocytic activity of blood neutrophils, with an acrophase occurring at the end of the light span. The present study, carried out on NMRI adult male mice kept on a LD 12:12 regimen, aimed to assess any circadian variation in the blood neutrophils' phagocytosis level. Basal phagocytic activity was tested against E. coli, every three hours of a 24 h cycle. The results show that phagocytosis in mice's blood neutrophils also presents a rhythmic circadian variation, whose acrophase is delayed with about eight hours compared to that in man, occurring in the second half of the dark period (3:00 h). The occurrence of high circadian phagocytic levels appears to be correlated with the activity type of the species and, of this point of view, mice cannot be used as a model for chronotherapeutical approaches in humans, without keeping in mind the differences between the time structure of the two species.