Preliminary research on possible relationship of NO with agmatine at the vascular level.

I Haulică, W Bild, R Iliescu, R Georgescu, F Frunză
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Abstract

The comparative study of the vascular effects of agmatine and L-arginine as physiological precursors of NO indicated the following: When administered intravenously, both vasoactive substances produced a decrease of the systemic blood pressure in rats and rabbits, diminished in the case of agmatine and suppressed in that of arginine by the previous administration of L-NAME. Myorelaxing vascular effects were obtained in isolated thoracic aorta rings, precontracted with phenylephrine and noradrenaline. Endothelium removal suppressed the myorelaxing properties of L-arginine, without affecting the effects of agmatine, both before and after administration of L-NAME or yohimbine. The persistence of the relaxing effects of agmatine after NOS and guanylate-cyclase inhibition with methylene blue excludes the participation of NO and cGMP in their occurrence. The enhancement of agmatine myorelaxation by moxonidine pleads for the stimulation of imidazoline receptors.

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血管水平一氧化氮与胍丁氨酸可能关系的初步研究。
对作为NO生理前体的胍丁氨酸和l -精氨酸的血管作用的比较研究表明:当静脉给药时,这两种血管活性物质都能降低大鼠和家兔的全身血压,胍丁氨酸的血压降低,精氨酸的血压被先前给药的L-NAME所抑制。用苯肾上腺素和去甲肾上腺素预收缩胸主动脉环,获得肌舒张血管效应。在给予L-NAME或育亨宾前后,内皮去除抑制了l -精氨酸的肌肉松弛特性,而不影响胍丁氨酸的作用。在NOS和亚甲基蓝抑制鸟苷酸环化酶后,胍丁氨酸的松弛作用持续存在,排除了NO和cGMP参与其发生。莫替尼定对胍丁氨酸肌松弛的增强是通过刺激咪唑啉受体实现的。
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