Merging the old skeletal biology with the new. II. Molecular aspects of bone formation and bone growth.

M M Cohen
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Abstract

Molecular aspects of bone formation and bone growth are discussed together with selected genetic disorders of the involved genes. Topics covered include: collagenopathies and osteogenesis imperfecta; core binding factor transcription factors and cleidocranial dysplasia; bone morphogenetic proteins and fibrodysplasia ossificans progressiva; transforming growth factor beta, suture closure, and craniosynostosis; Indian hedgehog, parathyroid hormone-related protein together with its receptor, and Jansen metaphyseal chondrodysplasia.

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将旧的骨骼生物与新的结合起来。2骨形成和骨生长的分子方面。
骨形成和骨生长的分子方面与选定的遗传疾病的相关基因一起讨论。涵盖的主题包括:胶原病和成骨不全;核心结合因子、转录因子与锁骨颅内发育不良的关系进行性骨化纤维发育不良与骨形态发生蛋白的关系转化生长因子,缝合和颅缝闭合;印度刺猬、甲状旁腺激素相关蛋白及其受体与詹森干骺端软骨发育不良。
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Hyaluronan is essential for the expansion of the cranial base growth plates. Vertical regulation of En-2 expression and eye development by FGFs and BMPs. Influences of osteoclast deficiency on craniofacial growth in osteopetrotic (op/op) mice. Merging the old skeletal biology with the new. I. Intramembranous ossification, endochondral ossification, ectopic bone, secondary cartilage, and pathologic considerations. Merging the old skeletal biology with the new. II. Molecular aspects of bone formation and bone growth.
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