Effects of prostaglandins (PGE1, PGE2, PGA1, PGF1 alpha) on the hypogastric nerves vas deferens and seminal vesicle preparations of the guinea pig [abstract].

Chimica therapeutica Pub Date : 1968-01-01
M K Naimzada
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引用次数: 0

Abstract

The effects of some naturally occurring prostaglandins (PGs) (PGE2, PGA1, and PGF1alpha) has been studied in vitro on the hypogastric nerves vas deferens and seminal vesicle preparations of the guinea pig and compared with that of PGE1. It has been shown that, like PGE1, PGE2, PGA1, and PGF1alpha are capable to increase markedly the effects of the sympathetic stimulation and of the sympathetic amines (adrenaline and noradrenaline) on the vas deferens and seminal vesicle of the guinea pig. PGE2, has however 1/10 and PGA1 and PGF1alpha 1/100 the potency of PGE1. It is suggested that, they may have a specific action in guinea pig enhancing the sensitivity of the semen excreting apparatus to nervous stimuli.

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前列腺素(PGE1、PGE2、PGA1、PGF1 α)对豚鼠胃下神经、输精管和精囊制备的影响[摘要]。
体外研究了几种天然前列腺素(PGE2、PGA1和PGF1alpha)对豚鼠胃下神经、输精管和精囊的影响,并与PGE1进行了比较。研究表明,与PGE1一样,PGE2、PGA1和pgf1 α能够显著增加交感刺激和交感胺(肾上腺素和去甲肾上腺素)对豚鼠输精管和精囊的作用。PGE2的效力是PGE1的1/10,PGA1和PGF1alpha的效力是PGE1的1/100。提示它们在豚鼠体内可能具有增强精液排泄器官对神经刺激敏感性的特殊作用。
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[Ethyltriphenylethylene compounds: synthesis and estrogenic and antifertility activities; partial dissociation between these two activities]. Effects of prostaglandins (PGE1, PGE2, PGA1, PGF1 alpha) on the hypogastric nerves vas deferens and seminal vesicle preparations of the guinea pig [abstract]. [Chemical aspects of steroidal contraceptives].
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