Microbial transformation of (+)-androsta-1 ,4-diene-3,17-dione by Cephalosporium aphidicola.

M Iqbal Choudhary, S Ghulam Musharraf, Farzana Shaheen, Atta-Ur-Rahman
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引用次数: 27

Abstract

Fermentation of (+)-androsta-1,4-diene-3,17-dione ([structure: see text]) with Cephalosporium aphidicola for 8 days yielded oxidative and reductive metabolites, androst-4-ene-3,17-dione ([structure: see text]), 17beta-hydroxyandrosta-1,4-diene-3-one ([structure: see text]), 11alpha-hydroxyandrosta-1,4-diene-3,17-dione ([structure: see text]), 11alpha-hydroxyandrost-4-ene-3,17-dione ([structure: see text]), 11alpha,17beta-dihydroxyandrost-4-ene-3-one ([structure: see text]) and 11alpha,17beta-dihydroxyandrosta-1,4-diene-3-one ([structure: see text]). The fermentation of [structure: see text] with Fusarium lini also yielded metabolites [structure: see text]. The structures of these metabolites were elucidated on the basis of spectroscopic techniques.

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蚜虫头孢菌对(+)-androsta- 1,4 -二烯-3,17-二酮的微生物转化
(+)-雄androst- 1,4-二烯-3,17-二酮([结构:见文])与aphidicola头孢菌发酵8天,产生氧化和还原代谢产物,雄androst-4-烯-3,17-二酮([结构:见文]),17β -羟基雄androta -1,4-二烯-3-酮([结构:见文]),11α -羟基雄androta -1,4-二烯-3,17-二酮([结构:见文]),11α -羟基雄androst-4-烯-3,17-二酮([结构:见文]),11α -羟基雄androst-4-烯-3,17-二酮([结构:见文]),11α, 17β -二羟基雄androst-4-烯-3-酮([结构:见文]))和11α, 17β -二羟基雄甾烷-1,4-二烯-3- 1(结构:见文本)。与镰刀菌发酵[结构:见文本]也产生代谢物[结构:见文本]。利用光谱技术对这些代谢产物的结构进行了分析。
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A new lignan glycoside and other constituents from Cephalaria ambrosioides. Highly oxygenated triterpenes from the roots of Atropa acuminata. Microbial transformation of (+)-androsta-1 ,4-diene-3,17-dione by Cephalosporium aphidicola. Separation and identification of Taxifolin 3-O-glucoside isomers from Chamaecyparis obtusa (Cupressaceae). Quinovic acid glycosides from Mitragyna stipulosa--first examples of natural inhibitors of snake venom phosphodiesterase I.
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