Fatty acid composition of phospholipids and cholesteryl esters in maternal serum in the early puerperium.

IF 2.9 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2003-05-01 DOI:10.1016/s0952-3278(03)00024-3

S R De Vriese, A B Christophe, M Maes

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引用次数: 10

Abstract

The fatty acid composition of serum phospholipids (PL) and cholesteryl esters (CE) in 26 healthy pregnant women at the end of term and 1 and 3 days after delivery was analysed in order to determine whether the maternal serum fatty acid composition changes in the early puerperium. The composition of the saturated fatty acids significantly changes in the PL fraction: 16:0 decreased and 18:0 increased. Both 20:4n-6 and 20:5 n-3 significantly increased after parturition in serum PL while 22:6n-3 remained constant at the three sampling time points. The sum of HUFA was slightly higher 3 days postpartum compared to the prepartum data. The essential fatty acid index significantly increased after delivery. In the CE fraction too differences occurred during puerperium: 18:2n-6 and 20:4n-6 increased and 18:1n-9 decreased after parturition. The sum of the n-3 fatty acids in CE remained unaltered. The EFA index significantly improved both in PL as in CE after delivery. In conclusion, the previously reported changes in the fatty acid composition of PL and CE during normal pregnancy diminish shortly after delivery. In fact, very soon after delivery the maternal fatty acid composition returns to more normal values.

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产褥期早期产妇血清中磷脂和胆固醇酯的脂肪酸组成。

本文对26例健康孕妇足月末及产后1、3天血清磷脂(PL)和胆固醇酯(CE)脂肪酸组成进行了分析，以确定产妇血清脂肪酸组成在产褥期早期是否发生变化。饱和脂肪酸组成在PL部分发生显著变化:16:0降低，18:0升高。分娩后血清PL中20:4n-6和20:5 n-3均显著升高，而22:6n-3在三个采样时间点保持不变。产后3天的HUFA总和略高于孕前数据。分娩后必需脂肪酸指数明显升高。CE分数在产褥期也存在差异:分娩后18:2n-6和20:4n-6升高，18:1n-9降低。CE中n-3脂肪酸的总量保持不变。分娩后，无论是PL还是CE, EFA指数都有了显著改善。总之，先前报道的正常妊娠期间PL和CE脂肪酸组成的变化在分娩后不久就消失了。事实上，分娩后不久，母体脂肪酸组成就会恢复到更正常的值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prostaglandins, leukotrienes, and essential fatty acids 医学-内分泌学与代谢

CiteScore

6.40

自引率

6.70%

发文量

审稿时长

13.2 weeks

期刊介绍： The role of lipids, including essential fatty acids and their prostaglandin, leukotriene and other derivatives, is now evident in almost all areas of biomedical science. Cell membrane behaviour and cell signalling in all tissues are highly dependent on the lipid constituents of cells. Prostaglandins, Leukotrienes & Essential Fatty Acids aims to cover all aspects of the roles of lipids in cellular, organ and whole organism function, and places a particular emphasis on human studies. Papers concerning all medical specialties are published. Much of the material is particularly relevant to the development of novel treatments for disease.