Liver oleic acid biogenesis is impaired during the prehypertensive period in the spontaneously hypertensive rat.

IF 2.9 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2003-07-01 DOI:10.1016/s0952-3278(03)00052-8

J-L Savelli, M Narce, V Fustier, J-P Poisson

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Abstract

In the present study, we have investigated the liver microsomal stearic acid delta9 desaturation, and the fatty acid composition of liver microsomal total lipids in 10- and 30-day-old spontaneously hypertensive rats (SHRs), compared to the normotensive Wistar Kyoto (WKY) control rats. So as to avoid any influence related to the diet, the composition of the milk being different in SHR and WKY strains, the pups were suckled by adoptive normotensive female Wistar. After weaning, the 30-day-old rats were fed a standard commercial diet and then killed. Our results show lower liver microsomal delta9 desaturase activities in the 10- and 30-day-old SHR versus the WKY of the same age. The fatty acid composition of the SHR liver microsomal total lipids are not in agreement with the changes in the delta9 desaturase activities at the two studied ages. This phenomenon depends not only on desaturation/elongation but also on other interacting aspects of lipid metabolism including oxidation, substrate availability, acyl exchange, and eicosanoid synthesis, as well as hormonal status.

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自发性高血压大鼠高血压前期肝油酸生物生成受损。

在本研究中，我们研究了10日龄和30日龄自发性高血压大鼠(SHRs)的肝微粒体硬脂酸δ ta9去饱和和肝微粒体总脂质的脂肪酸组成，并与正常血压的Wistar Kyoto (WKY)对照大鼠进行了比较。为避免饲粮的影响，SHR和WKY品系乳汁成分不同，采用过养的正常血压雌性Wistar喂养幼崽。断奶后，给30天大鼠喂食标准的商业饲料，然后杀死。我们的研究结果显示，10天和30日龄的SHR与同年龄的WKY相比，肝脏微体δ 9去饱和酶活性较低。SHR肝微粒体总脂质的脂肪酸组成与delta9去饱和酶活性在两个研究年龄的变化不一致。这种现象不仅取决于去饱和/延伸，还取决于脂质代谢的其他相互作用方面，包括氧化、底物可用性、酰基交换、类二十烷合成以及激素状态。

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来源期刊

Prostaglandins, leukotrienes, and essential fatty acids 医学-内分泌学与代谢

CiteScore

6.40

自引率

6.70%

发文量

审稿时长

13.2 weeks

期刊介绍： The role of lipids, including essential fatty acids and their prostaglandin, leukotriene and other derivatives, is now evident in almost all areas of biomedical science. Cell membrane behaviour and cell signalling in all tissues are highly dependent on the lipid constituents of cells. Prostaglandins, Leukotrienes & Essential Fatty Acids aims to cover all aspects of the roles of lipids in cellular, organ and whole organism function, and places a particular emphasis on human studies. Papers concerning all medical specialties are published. Much of the material is particularly relevant to the development of novel treatments for disease.