Conversion of α-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women

IF 3.2 Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2003-10-01 DOI:10.1016/S0952-3278(03)00111-X

G.C. Burdge, S.A. Wootton

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Abstract

The purpose of this study was to determine whether adult humans can recycle carbon from α-linolenic acid (18:3n-3) into saturated (SFA) and monounsaturated (MUFA) fatty acids. Six men and six women consumed 700 mg [U-¹³C]-18:3n-3. Blood was collected over 21 days and breath over 24 h. [¹³C]-labelled SFA and MUFA were detected in plasma phosphatidylcholine (PC) and triacylglycerol (TAG). Total labelled fatty acid incorporation into SFA and MUFA was five- and 25-fold greater in PC than TAG in men and women, respectively. [¹³C]-16:0 was the major labelled fatty acid in both fractions. Total [¹³C] incorporation into SFA and MUFA was 20% greater in men than women, and related positively (r²=0.35,P<0.05) to the fractional recovery of labelled 18:3n-3 as ¹³CO₂ on breath. These results suggest that the extent of partitioning towards β-oxidation and carbon recycling may regulate the availability of 18:3n-3 for conversion to longer-chain fatty acids.

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α-亚麻酸在男性和女性中转化为棕榈酸、棕榈油酸、硬脂酸和油酸

本研究的目的是确定成人是否可以将α-亚麻酸（18:3n-3）中的碳回收为饱和（SFA）和单不饱和（MUFA）脂肪酸。六名男性和六名女性摄入了700毫克[U-13C]-18:3n-3。在21天内采集血液，在24小时内呼吸。在血浆中检测[13C]标记的SFA和MUFA，分别检测磷脂酰胆碱（PC）和甘油三酯（TAG）。在男性和女性中，PC组中SFA和MUFA的总标记脂肪酸掺入量分别是TAG的5倍和25倍。[13C]-16:0是两个组分中主要的标记脂肪酸。男性在SFA和MUFA中的总[13C]掺入量比女性高20%，且与呼吸时标记为18:3n-3的13CO2分数回收率呈正相关（r2=0.35,P<0.05）。这些结果表明，β-氧化和碳循环的分配程度可能调节18:3n-3转化为长链脂肪酸的有效性。

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