Advances in photodynamic antimicrobial chemotherapy

IF 12.8 1区化学 Q1 CHEMISTRY, PHYSICAL Journal of Photochemistry and Photobiology C: Photochemistry Reviews Pub Date : 2021-12-01 DOI:10.1016/j.jphotochemrev.2021.100452

Abdulaziz Anas , Jeladhara Sobhanan , K.M. Sulfiya , C. Jasmin , P.K. Sreelakshmi , Vasudevanpillai Biju

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引用次数: 48

Abstract

Photodynamic therapy (PDT) and photodynamic antimicrobial chemotherapy (PACT) combine light and photosensitizers to treat cancers and microbial infections, respectively. In PACT, the excitation of a photosensitizer drug with appropriate light generates reactive oxygen species (ROS) that kill pathogens in the proximity of the drug. PACT has considerably advanced with new light sources, biocompatible photosensitizers, bioconjugate methods, and efficient ROS production. The PACT technology has evolved to compete with or replace antibiotics, reducing the burden of antibiotic resistance. This review updates recent advances in PACT, with special references to light sources, photosensitizers, and emerging applications to microbial infestations. We also discuss PACT applied to COVID-19 causing SARS-CoV-2 treatment and disinfecting food materials and water. Finally, we discuss the pathogen selectivity and efficiency of PACT.

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光动力抗菌化疗的研究进展

光动力疗法(PDT)和光动力抗菌化疗(PACT)分别结合光和光敏剂治疗癌症和微生物感染。在PACT中，用适当的光激发光敏剂药物产生活性氧(ROS)，杀死药物附近的病原体。PACT在新光源、生物相容性光敏剂、生物偶联方法和高效ROS生产方面取得了长足的进步。PACT技术已发展到与抗生素竞争或取代抗生素，减轻了抗生素耐药性的负担。这篇综述更新了PACT的最新进展，特别提到了光源、光敏剂和微生物感染的新应用。我们还讨论了PACT在COVID-19引起的SARS-CoV-2治疗和食品材料和水消毒中的应用。最后，我们讨论了PACT的病原菌选择性和效率。

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来源期刊

Journal of Photochemistry and Photobiology C: Photochemistry Reviews 化学-物理化学

CiteScore

21.90

自引率

0.70%

发文量

审稿时长

47 days

期刊介绍： The Journal of Photochemistry and Photobiology C: Photochemistry Reviews, published by Elsevier, is the official journal of the Japanese Photochemistry Association. It serves as a platform for scientists across various fields of photochemistry to communicate and collaborate, aiming to foster new interdisciplinary research areas. The journal covers a wide scope, including fundamental molecular photochemistry, organic and inorganic photochemistry, photoelectrochemistry, photocatalysis, solar energy conversion, photobiology, and more. It provides a forum for discussing advancements and promoting collaboration in the field of photochemistry.

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