The effect of methylprednisolone on mucopolysaccharides of rabbit vitreous humor and costal cartilage

Biochimica et Biophysica Acta (BBA) - Specialized Section on Mucoproteins and Mucopolysaccharides Pub Date : 1964-03-02 DOI:10.1016/0926-6526(64)90056-4

David Kaplan, Barry Fisher

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引用次数: 23

Abstract

Soluble methylprednisolone, given to rabbits in a dose of 3 mg in 1 ml intramuscularly per day causes (1) an increase in the concentration of mucopolysaccharide uronic acid in the vitreous humor compared with concentrations in a saline-treated control group, and (2) an increase in the absolute amount of mucopolysaccharide glucosamine in the costal cartilage of the same animals with an accompanying increased concentration of neutral sugar as measured by the anthrone reaction.

On the basis of data obtained, it is postulated that adrenal corticosteroids produce both an increase of hyaluronate in the vitreous humor and an increase in keratosulfate in costal cartilage.

It is thought that the most likely explanation of these phenomena is that these steroid hormones in small doses, regardless of whether or not they inhibit both synthesis and breakdown, cause an overall inhibition of degradation of these glucosamine-containing substances.

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甲基强的松龙对兔玻璃体和肋软骨粘多糖的影响

可溶性甲基强的松龙,给兔子3毫克的剂量每天1毫升肌肉的原因(1)粘多糖的浓度的增加糖醛酸的玻璃体与浓度在saline-treated对照组相比,和(2)的绝对数量的增加在肋软骨粘多糖葡萄糖胺浓度的增加与一篇相同的动物的中性糖蒽酮的反应。根据所获得的数据，我们假设肾上腺皮质类固醇既能增加玻璃体内的透明质酸，又能增加肋软骨内的硫酸角化物。人们认为，对这些现象最可能的解释是，这些小剂量的类固醇激素，无论它们是否抑制合成和分解，都会导致这些含氨基物质的降解受到全面抑制。

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Biochimica et Biophysica Acta (BBA) - Specialized Section on Mucoproteins and Mucopolysaccharides

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