{"title":"The intracellular localization of an enzymatic defect of lipid metabolism in diabetic rats","authors":"Alfred Gellhorn, William Benjamin","doi":"10.1016/0926-6542(64)90073-3","DOIUrl":null,"url":null,"abstract":"<div><p>The conversion of stearic acid to oleic acid has been studied in homogenates and other subcellular fractions of adipose tissues and liver of untreated and insulin-treated diabetic rats and rats maintained on a fat-free diet. The synthesis of the monounsaturrated fatty acid is an oxygenase reaction requiring molecular oxygen and DPNH or TPNH. The site of the reaction has been localized to the microsomes.</p><p>In diabetes, the microsomal enzymatic conversion of strearate to oleate stops. This defect in lipid metabolism, which is separable from the overall depression of lipid biosynthesis, is corrected by insulin therapy.</p></div>","PeriodicalId":100171,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects","volume":"84 2","pages":"Pages 167-175"},"PeriodicalIF":0.0000,"publicationDate":"1964-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6542(64)90073-3","citationCount":"128","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0926654264900733","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 128
Abstract
The conversion of stearic acid to oleic acid has been studied in homogenates and other subcellular fractions of adipose tissues and liver of untreated and insulin-treated diabetic rats and rats maintained on a fat-free diet. The synthesis of the monounsaturrated fatty acid is an oxygenase reaction requiring molecular oxygen and DPNH or TPNH. The site of the reaction has been localized to the microsomes.
In diabetes, the microsomal enzymatic conversion of strearate to oleate stops. This defect in lipid metabolism, which is separable from the overall depression of lipid biosynthesis, is corrected by insulin therapy.
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