Investigation into a possible association between oral lichen planus, the human herpesviruses, and the human papillomaviruses.

Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology Pub Date : 2003-01-01 DOI:10.1007/BF03260023

Cathal OFlatharta, Stephen R Flint, Mary Toner, David Butler, Mohamed J E M F Mabruk

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引用次数: 27

Abstract

Background: Oral lichen planus (OLP) is a chronic relapsing cell-mediated condition of unknown etiology. The purpose of this study was to ascertain if the human herpesviruses (HHVs) or human papillomaviruses (HPVs) act as possible factors or co-factors in the pathogenesis of OLP.

Methods: Thirty-eight histologically confirmed OLP and 20 normal control buccal mucosa tissue samples were analyzed. Polymerase chain reaction analysis was employed to detect members of the HHV and HPV families.

Results: The Epstein-Barr virus and HHV-7 were detected in a small percentage of tissue samples. However, HPV-16 was detected in 26.3% of OLP samples and 0% of the normal control tissues. The epidermodysplasia verruciformis-related HPV types were detected in 42% of OLP samples and 45% of normal control samples.

Conclusion: The results of this study do not suggest a causative role for members of the HHV family in the pathology of OLP. However, a statistical association was found between HPV-16 presence and OLP.

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口腔扁平苔藓、人疱疹病毒和人乳头瘤病毒之间可能关系的调查。

背景:口腔扁平苔藓(OLP)是一种慢性复发的细胞介导的疾病，病因不明。本研究的目的是确定人疱疹病毒(hhv)或人乳头瘤病毒(hpv)是否作为OLP发病的可能因素或辅助因素。方法:对组织学证实的OLP 38例和正常对照组20例进行分析。采用聚合酶链反应法检测HHV和HPV家族成员。结果:在少量组织样本中检测到eb病毒和HHV-7。然而，在26.3%的OLP样本和0%的正常对照组织中检测到HPV-16。在42%的OLP样本和45%的正常对照样本中检测到与疣状增生相关的HPV类型。结论:本研究结果不提示HHV家族成员在OLP病理中的致病作用。然而，HPV-16的存在与OLP之间存在统计学关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology

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