Psychoses and creativity: is the missing link a biological mechanism related to phospholipids turnover?

IF 2.9 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2003-12-01 DOI:10.1016/j.plefa.2003.08.019

Bradley S Folley, Mikisha L Doop, Sohee Park

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引用次数: 18

Abstract

Recent evidence suggests that genetic and biochemical factors associated with psychoses may also provide an increased propensity to think creatively. The evolutionary theories linking brain growth and diet to the appearance of creative endeavors have been made recently, but they lack a direct link to research on the biological correlates of divergent and creative thought. Expanding upon Horrobin's theory that changes in brain size and in neural microconnectivity came about as a result of changes in dietary fat and phospholipid incorporation of highly unsaturated fatty acids, we propose a theory relating phospholipase A2 (PLA2) activity to the neuromodulatory effects of the noradrenergic system. This theory offers probable links between attention, divergent thinking, and arousal through a mechanism that emphasizes optimal individual functioning of the PLA2 and NE systems as they interact with structural and biochemical states of the brain. We hope that this theory will stimulate new research in the neural basis of creativity and its connection to psychoses.

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精神病和创造力:缺失的环节是与磷脂周转有关的生物机制吗?

最近的证据表明，与精神病相关的遗传和生化因素也可能增加创造性思维的倾向。最近出现了将大脑发育和饮食与创造性活动的出现联系起来的进化理论，但它们缺乏与发散性思维和创造性思维的生物学相关性研究的直接联系。Horrobin的理论认为，大脑大小和神经微连通性的变化是饮食脂肪和高度不饱和脂肪酸的磷脂结合变化的结果，在此基础上，我们提出了磷脂酶A2 (PLA2)活性与去甲肾上腺素能系统的神经调节作用相关的理论。该理论通过强调PLA2和NE系统在与大脑结构和生化状态相互作用时的最佳个体功能的机制，提供了注意力、发散思维和觉醒之间的可能联系。我们希望这一理论能够激发关于创造力的神经基础及其与精神病的联系的新研究。

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来源期刊

Prostaglandins, leukotrienes, and essential fatty acids 医学-内分泌学与代谢

CiteScore

6.40

自引率

6.70%

发文量

审稿时长

13.2 weeks

期刊介绍： The role of lipids, including essential fatty acids and their prostaglandin, leukotriene and other derivatives, is now evident in almost all areas of biomedical science. Cell membrane behaviour and cell signalling in all tissues are highly dependent on the lipid constituents of cells. Prostaglandins, Leukotrienes & Essential Fatty Acids aims to cover all aspects of the roles of lipids in cellular, organ and whole organism function, and places a particular emphasis on human studies. Papers concerning all medical specialties are published. Much of the material is particularly relevant to the development of novel treatments for disease.