Papillary microcarcinoma of the thyroid gland: analysis of prognostic factors including histological subtype.

Laura Falvo, Claudia D'Ercole, Salvatore Sorrenti, Vito D'Andrea, Antonio Catania, Alberto Berni, Paola Grilli, Enrico De Antoni
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Abstract

Objective: To evaluate the prognosis of papillary microcarcinoma (PMC) of the thyroid.

Design: Prospective study.

Setting: Teaching hospital, Italy.

Subjects: 89 patients treated for papillary micro carcinoma of thyroid and followed up for at least 6 years (range 6-12).

Intervention: Total thyroidectomy and, for lymph node metastases, laterocervical lymphadenectomy.

Main outcome measures: Sex distribution, mode of onset of disease, diameter of tumour, histological type, histological stage, presence of lymph node metastases at the time of operation and type of operation.

Results: When the disease presented with laterocervical lymph nodes it was histologically more aggressive and included follicular (n = 3) and sclerosing (n = 4) types.

Conclusion: Papillary microcarcinoma has an excellent prognosis if managed initially by total thyroidectomy.

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甲状腺乳头状微癌:包括组织学亚型在内的预后因素分析。
目的:探讨甲状腺微乳头状癌(PMC)的预后。设计:前瞻性研究。环境:意大利教学医院。对象:89例甲状腺乳头状微癌患者,随访至少6年(范围6-12年)。干预:全甲状腺切除术,对于淋巴结转移,颈侧淋巴结切除术。主要观察指标:性别分布、发病方式、肿瘤直径、组织学类型、组织学分期、手术时有无淋巴结转移、手术类型。结果:当该病表现为颈侧淋巴结时,其组织学上更具侵袭性,包括滤泡型(n = 3)和硬化型(n = 4)。结论:乳头状微癌早期行甲状腺全切除术预后良好。
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