α-1-ANTICHYMOTRYPSIN POLYMORPHISM IN THE GENE PROMOTER REGION AFFECTS SURVIVAL AND SYNAPSIS LOSS IN ALZHEIMER’S DISEASE

IF 3.8 3区 医学 Q2 GERIATRICS & GERONTOLOGY Archives of gerontology and geriatrics Pub Date : 2004-01-01 DOI:10.1016/j.archger.2004.04.034
F. LICASTRO , M. CHIAPPELLI , L.J. THAL , E. MASLIAH
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α-1抗凝乳胰蛋白酶基因启动子区多态性影响阿尔茨海默病患者的生存和突触丧失
对130例经神经病理学证实的阿尔茨海默病(AD)患者进行了载脂蛋白Eepsilon (APOE)多态性区域和α -1抗凝乳胰蛋白酶(ACT)基因启动子区域新多态性的基因分型。ACT TT基因型与AD患者较长的生存期相关,并且在APOE ε 4等位基因患者中,该基因型增加了疾病的持续时间。ACT TT基因型也与没有APOE ε 4等位基因的患者发病年龄较晚和死亡年龄较晚相关。后一组患者也表现出中额叶(MF)皮层突触素水平的增加。ACT似乎在AD中发挥着复杂的、多重的作用,并影响没有APOE - epsilon4等位基因的AD患者大脑中的突触可塑性。
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来源期刊
CiteScore
7.30
自引率
5.00%
发文量
198
审稿时长
16 days
期刊介绍: Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.
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