A QUALITATIVE ANALYSIS OF THE MINI MENTAL STATE EXAMINATION ON ALZHEIMER’S DISEASE PATIENTS TREATED WITH CHOLINESTERASE INHIBITORS

IF 3.8 3区 医学 Q2 GERIATRICS & GERONTOLOGY Archives of gerontology and geriatrics Pub Date : 2004-01-01 DOI:10.1016/j.archger.2004.04.035
E. LUCCHI , N. MINICUCI , F. MAGNIFICO , S. MONDINI , A. CALZA , S. AVANZI , D. VILLANI , G. BELLELLI , M. TRABUCCHI
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胆碱酯酶抑制剂治疗阿尔茨海默病患者精神状态检查的定性分析
在阿尔茨海默病(AD)受试者中,胆碱酯酶抑制剂(ChEls)对认知能力的改善并不均匀。本研究的目的是评估在ChEls治疗9个月后,AD患者是否可以观察到迷你精神状态检查(MMSE)的特定变化模式。从2000年9月到2002年9月,99名受试者参加了CRONOS项目。他们以前从未接受过ChEls治疗。所有患者均完成了3个月和9个月的随访。多维度评估包括MMSE、日常生活活动(ADL)、日常生活工具活动(IADL)、躯体健康状况,根据CRONOSproject设计。MMSE作为总分和11个分项进行分析。根据MMSE总分自基线至第9个月的变化程度分为2组。变化为0的受试者为应答者(R)。开始时,两组间无统计学差异。R组MMSE评分在3个月(p < 0.0001)和9个月时均显著高于R组(p < 0.0001),而NR组功能状态(ADL和IADL)在9个月时均显著低于R组(p = 0.025;P =0.018)。在3个月的MMSE定性分析中,NR在颞部明显恶化(p
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来源期刊
CiteScore
7.30
自引率
5.00%
发文量
198
审稿时长
16 days
期刊介绍: Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.
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