ALZHEIMER’S DISEASE AND ACETYLCHOLINESTERASE INHIBITOR AGENTS: A TWO-YEAR LONGITUDINAL STUDY

IF 3.8 3区 医学 Q2 GERIATRICS & GERONTOLOGY Archives of gerontology and geriatrics Pub Date : 2004-01-01 DOI:10.1016/j.archger.2004.04.026
C. FUSCHILLO , E. ASCOLI , G. FRANZESE , F. CAMPANA , C. CELLO , M. GALDI , S. LA PIA , C. CETRANGOLO
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阿尔茨海默病和乙酰胆碱酯酶抑制剂:一项为期两年的纵向研究
阿尔茨海默病(AD)是最常见的与年龄相关的神经退行性疾病,在世界许多地区都是一个紧迫的公共卫生问题。我们介绍了在“CRONOS”项目(CP)的头两年里,一个名为“阿尔茨海默病评估单位”(UVA)的特设病房的活动结果。我们评估了乙酰胆碱酯酶抑制剂(ache - 1)治疗轻中度AD和UVA服务人群的有效性和安全性。354个病人因为认知缺陷来我们病房就诊。根据CP标准,66例患者(42例女性,24例男性,平均年龄74.1±5.8岁)入组研究。在基线和3、9、15和21个月后进行评估。我们的研究结果显示,在治疗的前9个月,这些药物对轻度至中度AD患者有积极的影响。在这段时间之后,我们观察到迷你精神状态检查(MMSE)得分逐渐下降,每年整体损伤0.9- 1.0分。不良事件一般不麻烦。我们的数据强烈支持UVA在疾病早期确定AD病例的有用性。此外,CP提供了关于这一重要和毁灭性疾病的更全面的知识。
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来源期刊
CiteScore
7.30
自引率
5.00%
发文量
198
审稿时长
16 days
期刊介绍: Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.
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