Joanna Tołwińska, Barbara Głowińska, Mirosława Urban
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引用次数: 0
Abstract
Introduction: According to very well documented onset of atherosclerosis in early childhood, scientists are looking for good diagnostic methods for evaluating first changes in arterial blood vessels noninvasively. We want to know more about the pathogenetic mechanisms and about changes in vessels especially in group of young people with risk factors of premature atherosclerosis. The significance of endothelial dysfunction in very early phase of this process is known very well so far. High resolution echocardiography seems to be a good method which allows to examine arteries in children and adolescents. Because of localization, brachial and carotid arteries are very good field for this kind of examinations. THE AIM of this study was the evaluation with high resolution echocardiography of endothelial function in type 1 diabetes children and adolescents. We also measured the intimal plus medial thickness in carotid communis arteries (IMT).
Material and methods: We examined a group of 64 children (29 boys and 35 girls) aged 14.8-16.2 yr (mean 15.5 yr) suffering from diabetes type 1. The control group consisted of 24 children (9 boys, 15 girls) in similar age. Using high resolution echocardiography, B-mode images, we measured in the diastole phase, distance "m-m" in brachial arteries (distance between two "m" lines which are borders among media and adventitia of near and far wall of the artery) at rest, during reactive hyperaemia (with increased flow causing endothelium-dependent dilatation FMD), again at rest and after sublingual glyceryl trinitrate (causing endothelium-independent dilatation NTGMD). Using Doppler technic we evaluated baseline flow and calculated the degree of reactive hyperemia. We also measured intimal plus medial thickness in every carotid artery three times and calculated mean value. In our analysis we estimated the concentrations of cholesterol, HDL- cholesterol, LDL-cholesterol and triglycerides.
Results: We noticed higher IMT values in the whole examined group compared to the control group (0.52 mm vs. 0.43 mm, p<0.05). In diabetic children the vessel size was similar to control group but FMD was significantly impaired (5.56% vs. 9.47%, p<0.05). The level of triglycerides and total cholesterol was higher in the examined group.
Conclusions: 1. The evaluation of IMT in the carotid arteries in patients with type 1 diabetes showed a more advanced degree of atherosclerotic changes in this group compared to healthy controls. 2. FMD evaluated in brachial artery is a usefull tool in assessing impaired endothelial function in people suffering from the risks factors of atherosclerosis. 3. Ultrasonographic methods of evaluating atherosclerotic changes in arterial vessels should be more often used in practice as relatively easy, noninvasive and inexpensive.
导读:根据对儿童早期动脉粥样硬化发病的详细记录,科学家们正在寻找良好的诊断方法,以无创地评估动脉血管的首次变化。我们想要了解更多的发病机制和血管的变化,特别是在有过早动脉粥样硬化危险因素的年轻人群体中。到目前为止,内皮功能障碍在这一过程的早期阶段的重要性是众所周知的。高分辨率超声心动图似乎是一个很好的方法,允许检查动脉在儿童和青少年。由于定位,臂动脉和颈动脉是很好的检查领域。本研究的目的是用高分辨率超声心动图评价1型糖尿病儿童和青少年的内皮功能。我们还测量了颈动脉社区动脉(IMT)的内膜和内侧厚度。材料和方法:我们检查了64名儿童(29名男孩和35名女孩),年龄14.8-16.2岁(平均15.5岁),患有1型糖尿病。对照组为24例同龄儿童(男童9例,女童15例)。使用高分辨率超声心动图,b型图像,我们测量了舒张期肱动脉的距离“m-m”(两条“m”线之间的距离,即动脉近壁和远壁的中膜和外膜之间的边界),静止时,反应性充血期间(流量增加导致内皮依赖性扩张FMD),再次静止时和舌下三硝酸甘油(导致内皮依赖性扩张NTGMD)。采用多普勒技术评估基线血流并计算反应性充血的程度。我们还测量了每条颈动脉的内膜和内侧厚度三次,并计算了平均值。在我们的分析中,我们估计了胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯的浓度。结果:我们注意到,与对照组相比,整个检查组的IMT值更高(0.52 mm vs. 0.43 mm)。对1型糖尿病患者颈动脉IMT的评估显示,与健康对照组相比,该组患者的动脉粥样硬化改变程度更高。2. 肱动脉FMD评估是评估动脉粥样硬化危险因素患者内皮功能受损的有用工具。3.超声检查动脉粥样硬化改变的方法相对简单、无创且价格低廉,因此应在实践中得到更多的应用。