Injections of botulinum A toxin for the treatment of anal fissures.

The European journal of surgery = Acta chirurgica Pub Date : 2002-01-01 DOI:10.1080/11024150201680030

Radzisław Trzciński, Adam Dziki, Marcin Tchórzewski

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引用次数: 13

Abstract

Objective: To find out how injections of botulinum A toxin influence the healing of anal fissures.

Design: Retrospective study.

Setting: Medical University of Lodz, Poland.

Subjects: 13 patients (6 women, 7 men), mean age 49 (range 31-78), treated with injections of botulinum A toxin 50 units on either side of the anal fissure into the internal anal sphincter from May to December 1999.

Main outcome measures: Complications and relapse.

Results: Seven fissures had healed by one month and four by two months. Two remained unhealed but asymptomatic. There was no incontinence of flatus or faeces after three months of treatment. Resting anal pressure was significantly lower in 10 of 13 patients compared with before treatment (p < 0.05). One fissure relapsed after 4 months and this patient had a successful anal stretch.

Conclusion: Injection of botulinum A toxin gives good results in the treatment of anal fissures.

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注射肉毒杆菌A毒素治疗肛裂。

目的:探讨注射A型肉毒杆菌毒素对肛裂愈合的影响。设计:回顾性研究。地点:波兰罗兹医科大学。对象:1999年5月~ 12月，13例患者(女6例，男7例)，平均年龄49岁(31 ~ 78岁)，分别于肛裂两侧内肛门括约肌注射A型肉毒杆菌毒素50单位。主要观察指标:并发症和复发。结果:7例1个月愈合，4例2个月愈合。2例未痊愈但无症状。治疗3个月后，患者无排便或排便失禁。13例患者中有10例静息肛压较治疗前明显降低(p < 0.05)。一个裂缝复发后4个月，这名患者有一个成功的肛门拉伸。结论:注射A型肉毒杆菌毒素治疗肛裂效果良好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The European journal of surgery = Acta chirurgica

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