TGF-beta signal transduction in oro-facial health and non-malignant disease (part I).

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists Pub Date : 2004-11-01 DOI:10.1177/154411130401500602

S S Prime, M Pring, M Davies, I C Paterson

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引用次数: 52

Abstract

The transforming growth factor-beta (TGF-beta) family of cytokines consists of multi-functional polypeptides that regulate a variety of cell processes, including proliferation, differentiation, apoptosis, extracellular matrix elaboration, angiogenesis, and immune suppression, among others. In so doing, TGF-beta plays a key role in the control of cell behavior in both health and disease. In this report, we review what is known about the mechanisms of activation of the peptide, together with details of TGF-beta signal transduction pathways. This review summarizes the evidence implicating TGF-beta in normal physiological processes of the craniofacial complex-such as palatogenesis, tooth formation, wound healing, and scarring-and then evaluates its role in non-malignant disease processes such as scleroderma, submucous fibrosis, periodontal disease, and lichen planus.

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口腔-面部健康和非恶性疾病中的tgf - β信号转导(第一部分)。

转化生长因子- β (tgf - β)细胞因子家族由多种功能多肽组成，可调节多种细胞过程，包括增殖、分化、凋亡、细胞外基质细化、血管生成和免疫抑制等。在这样做的过程中，tgf - β在控制健康和疾病的细胞行为中起着关键作用。在本报告中，我们回顾了已知的肽激活机制，以及tgf - β信号转导途径的细节。本文综述了tgf - β参与颅面复合体正常生理过程的证据，如腭形成、牙齿形成、伤口愈合和瘢痕形成，然后评估其在非恶性疾病过程中的作用，如硬皮病、粘膜下纤维化、牙周病和扁平苔藓。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists

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