[Serum levels of antibodies for IgG, IgA, and IgM against the fungi antigen in psoriasis vulgaris].

Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University Pub Date : 2003-12-01

Yun-sheng Liang, Hai-quan Wen, Rong Xiao

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Abstract

Objective: To detect the serum levels of antibodies against Malassezia further and Candida albicans in patients with psoriasis vulgaris (PV), and to investigate the relationship between Malassezia furfur or Candida albicans and pathogenesis of PV.

Methods: The serum levels of antibodies for IgG, IgA, and IgM against the whole cell antigen Wag and soluble antigen (Sag) of Malassezia fufur and Candida albicans in 40 PV patients and 20 healthy controls were detected by indirect-ELISA, RESULTS: The serum levels of IgG against Wag of Malassezia furfur and Candida albicans were significantly higher in PV patients than those in the healthy controls (P < 0.01, P < 0.05, respectively), The serum levels of IgM against Sag of Malassezia furfur and Candida albican, IgA against Sag of Candida albicans were significantly lower in PV patients than those in the healthy controls (P < 0.05).

Conclusion: There are some humoral immunity abnormalties in PV patients. Malassezia furfur and Candida albicans may be related to the pathogenesis of PV.

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[寻常型银屑病血清抗真菌抗原IgG、IgA和IgM抗体水平]。

目的:进一步检测寻常型银屑病患者血清马拉色菌和白色念珠菌抗体水平，探讨毛马拉色菌和白色念珠菌与银屑病发病的关系。方法:采用间接elisa法检测40例PV患者和20例健康对照者血清抗马拉色菌和白色念珠菌全细胞抗原Wag和可溶性抗原Sag的IgG、IgA和IgM抗体水平。PV患者血清抗毛马拉色菌和白色念珠菌Wag IgG水平显著高于健康对照组(P < 0.01, P < 0.05)，血清抗毛马拉色菌和白色念珠菌Sag IgM和抗白色念珠菌Sag IgA水平显著低于健康对照组(P < 0.05)。结论:PV患者存在一定的体液免疫异常。毛马拉色菌和白色念珠菌可能与PV的发病机制有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University

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