Techniques of SNP genotyping and remote sensing applied for elucidation of the contribution of polygene and environmental factors to inter-individual variation in skin pigmentation phenotype.

Sumiko Anno, Susumu Kudo, Keita Hamasaki, Kazunari Matsumura, Takushi Yamamoto, Koretsugu Ogata
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引用次数: 2

Abstract

We present a conceptual framework for applying techniques of SNP genotyping as a molecular biological approach and remote sensing as an ecological approach to elucidation of the contribution of polygene and environmental factors to inter-individual variation in skin pigmentation phenotype. Additionally, we discuss the obstacles that frustrate our efforts to identify how the human genome encodes the complex phenotype and suggest the use of computational methods designed for knowledge discovery within hereditary database.

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应用SNP基因分型和遥感技术研究多基因和环境因素对皮肤色素沉着表型个体间变异的影响。
我们提出了一个概念框架,将SNP基因分型技术作为分子生物学方法和遥感技术作为生态学方法来阐明多基因和环境因素对皮肤色素沉着表型个体间差异的贡献。此外,我们讨论了阻碍我们识别人类基因组如何编码复杂表型的障碍,并建议使用遗传数据库中知识发现的计算方法。
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