{"title":"Morphological changes in adrenal cortex--the final effect of angiotensin II receptor antagonists.","authors":"Teresa Masłyk, Jadwiga Romanowska-Sarlej, Ewa Kifer-Wysocka, Włodzimierz Matysiak, Krystyna Czerny","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The influence of losartan, angiotensin receptor on the histological image of the adrenal glomerular layer of white rats was revealed. The drug was administered in the therapeutic and ten times higher dose. It was manifested by the decrease of glandular cells and prevalence of blastic cells of the cortex. After a 2-month break in drug administration, the reconstruction of glandular cells was noticed, which could indicate that the observed changes are of transitory character.</p>","PeriodicalId":8245,"journal":{"name":"Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina","volume":"59 2","pages":"129-33"},"PeriodicalIF":0.0000,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The influence of losartan, angiotensin receptor on the histological image of the adrenal glomerular layer of white rats was revealed. The drug was administered in the therapeutic and ten times higher dose. It was manifested by the decrease of glandular cells and prevalence of blastic cells of the cortex. After a 2-month break in drug administration, the reconstruction of glandular cells was noticed, which could indicate that the observed changes are of transitory character.
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