Resilience in Development and Psychopathology: Multisystem Perspectives.

IF 4 2区 医学 Q2 CHEMISTRY, MEDICINAL ACS Infectious Diseases Pub Date : 2021-05-07 Epub Date: 2021-02-03 DOI:10.1146/annurev-clinpsy-081219-120307
Ann S Masten, Cara M Lucke, Kayla M Nelson, Isabella C Stallworthy
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引用次数: 211

Abstract

Resilience science in psychology and related fields emerged from clinical research on risk for psychopathology in the 1970s and matured over the ensuing decades with advances in theory, methods, and knowledge. Definitions and models of resilience shifted to reflect the expanding influence of developmental systems theory and the growing need to integrate knowledge about resilience across levels and disciplines to address multisystem threats. Resilience is defined for scalability and integrative purposes as the capacity of a dynamic system to adapt successfully through multisystem processes to challenges that threaten system function, survival, or development. Striking alignment of resilience factors observed in human systems, ranging from individuals to communities, suggests the possibility of networked, multisystem protective factors that work in concert. Evidence suggests that there may be resilience factors that provide transdiagnostic protection against the effects of adverse childhood experiences on risk for psychopathology. Multisystem studies of resilience offer promising directions for future research and its applications to promote mental health and positive development in children and youth at risk for psychopathology.

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弹性在发展和精神病理学:多系统的观点。
心理学及相关领域的弹性科学始于20世纪70年代对精神病理风险的临床研究,并在随后的几十年里随着理论、方法和知识的进步而成熟起来。弹性的定义和模型发生了变化,以反映发展系统理论日益扩大的影响,以及越来越需要跨层次和学科整合有关弹性的知识,以应对多系统威胁。弹性被定义为可伸缩性和集成目的,作为动态系统通过多系统过程成功适应威胁系统功能、生存或发展的挑战的能力。在从个人到社区的人类系统中观察到的恢复力因素的惊人一致性表明,可能存在协同工作的网络化多系统保护因素。有证据表明,可能存在弹性因素提供跨诊断保护,以防止不良童年经历对精神病理风险的影响。弹性的多系统研究为未来的研究和应用提供了有希望的方向,以促进精神病理风险儿童和青少年的心理健康和积极发展。
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来源期刊
ACS Infectious Diseases
ACS Infectious Diseases CHEMISTRY, MEDICINALINFECTIOUS DISEASES&nb-INFECTIOUS DISEASES
CiteScore
9.70
自引率
3.80%
发文量
213
期刊介绍: ACS Infectious Diseases will be the first journal to highlight chemistry and its role in this multidisciplinary and collaborative research area. The journal will cover a diverse array of topics including, but not limited to: * Discovery and development of new antimicrobial agents — identified through target- or phenotypic-based approaches as well as compounds that induce synergy with antimicrobials. * Characterization and validation of drug target or pathways — use of single target and genome-wide knockdown and knockouts, biochemical studies, structural biology, new technologies to facilitate characterization and prioritization of potential drug targets. * Mechanism of drug resistance — fundamental research that advances our understanding of resistance; strategies to prevent resistance. * Mechanisms of action — use of genetic, metabolomic, and activity- and affinity-based protein profiling to elucidate the mechanism of action of clinical and experimental antimicrobial agents. * Host-pathogen interactions — tools for studying host-pathogen interactions, cellular biochemistry of hosts and pathogens, and molecular interactions of pathogens with host microbiota. * Small molecule vaccine adjuvants for infectious disease. * Viral and bacterial biochemistry and molecular biology.
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