Developmental Perspectives on the Study of Persons with Intellectual Disability.

IF 4 2区 医学 Q2 CHEMISTRY, MEDICINAL ACS Infectious Diseases Pub Date : 2021-05-07 Epub Date: 2021-02-09 DOI:10.1146/annurev-clinpsy-081219-090532
Jacob A Burack, David W Evans, Natalie Russo, Jenilee-Sarah Napoleon, Karen J Goldman, Grace Iarocci
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引用次数: 23

Abstract

Developmental approaches provide inclusive, universal, and methodologically rigorous frameworks for studying persons with intellectual disability (ID). This is an exceptionally heterogeneous group with regard to etiology, genotype, and phenotype that simply shares the traditional diagnostic criteria, typically a score of two standard deviations below the population mean of 100 on standardized IQ tests and deficits in adaptive behavior. We trace the foundational, conceptual, and methodological roots of developmental approaches and highlight ways that these and more recent iterations continue to be central to advances in the increasingly nuanced study of persons with ID. This work is premised on the consideration of specific etiological groupings and subgroupings across and between different domains of functioning within the context of familial and complex environments throughout the life span. We highlight the potential contributions of advances in behavioral methodologies, genomics, and neuroscience when considered within universal and hierarchic frameworks based on development.

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智障人士研究的发展视角。
发展方法为研究智障人士提供了包容、普遍和方法严谨的框架。在病因、基因型和表型方面,这是一个异常异质的群体,他们只是共享传统的诊断标准,通常在标准化智商测试中得分低于100分的人群平均水平两个标准差,并且在适应行为方面存在缺陷。我们追溯了发展方法的基础、概念和方法论根源,并强调了这些方法以及最近的迭代方法,这些方法仍然是对ID患者日益细致的研究进展的核心。这项工作的前提是考虑在整个生命周期的家庭和复杂环境的背景下,在不同的功能领域之间和之间的特定病因组和亚组。我们强调在基于发展的普遍和层次框架中考虑行为方法、基因组学和神经科学的进步的潜在贡献。
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来源期刊
ACS Infectious Diseases
ACS Infectious Diseases CHEMISTRY, MEDICINALINFECTIOUS DISEASES&nb-INFECTIOUS DISEASES
CiteScore
9.70
自引率
3.80%
发文量
213
期刊介绍: ACS Infectious Diseases will be the first journal to highlight chemistry and its role in this multidisciplinary and collaborative research area. The journal will cover a diverse array of topics including, but not limited to: * Discovery and development of new antimicrobial agents — identified through target- or phenotypic-based approaches as well as compounds that induce synergy with antimicrobials. * Characterization and validation of drug target or pathways — use of single target and genome-wide knockdown and knockouts, biochemical studies, structural biology, new technologies to facilitate characterization and prioritization of potential drug targets. * Mechanism of drug resistance — fundamental research that advances our understanding of resistance; strategies to prevent resistance. * Mechanisms of action — use of genetic, metabolomic, and activity- and affinity-based protein profiling to elucidate the mechanism of action of clinical and experimental antimicrobial agents. * Host-pathogen interactions — tools for studying host-pathogen interactions, cellular biochemistry of hosts and pathogens, and molecular interactions of pathogens with host microbiota. * Small molecule vaccine adjuvants for infectious disease. * Viral and bacterial biochemistry and molecular biology.
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