Prevalence and Intensity of Schistosoma mansoni Infection and Its Associated Risk Factors Among Patients with and without HIV at Chuahit Health Center, Dembia District, Northwest Ethiopia.
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引用次数: 1
Abstract
Background: Human Immunodeficiency Virus-1/AIDS and Schistosoma mansoni are widely spread in sub-Saharan Africa including Ethiopia and the co-infection is also prevalent, occurs commonly. Schistosoma mansoni infection has been suggested to be a risk factor for HIV transmission and progression. This study aims to assess the prevalence and intensity of Schistosoma mansoni infection and associated risk factors among individuals with and without human immunodeficiency virus (HIV) at Chuahit Health Center, West Dembia, Northwest Ethiopia.
Methods: Institutional based cross-sectional study was conducted from March to April 2019. Two hundred sixty-six study subjects were included in the study by using a systemic and convenient sampling technique. Pretested structured questionnaire was employed to collect data. Single stool samples were collected and examined for S. mansoni eggs. Finger prick and venous blood samples were collected for HIV-1 screening and viral load count. Data were analyzed using SPSS version 20. Independent t-test and one-way ANOVA were used to compare the mean of egg counts with HIV status and viral load counts, respectively. A P-value of less than 0.05 was taken as statistically significant.
Results: The overall prevalence and intensity of S. mansoni infection was 41 (15.4%) and 162.24 egg per gram of faeces (EPG), respectively. Prevalence of S. mansoni was higher in seronegative study participants though the difference is statistically insignificant. Higher intensity of infection was observed among seropositive study participants with high viral load counts (>1000 copies/mL).
Conclusion: Relatively higher prevalence and intensity of S. mansoni infection were found. Study participants' occupation was identified as potential risk factor to S. mansoni infection. Further studies are needed to know the impact of HIV on the prevalence and intensity of S. mansoni infection in the study area.
背景:人类免疫缺陷病毒-1/艾滋病和曼氏血吸虫在包括埃塞俄比亚在内的撒哈拉以南非洲地区广泛传播，合并感染也很普遍。曼氏血吸虫感染已被认为是艾滋病毒传播和发展的一个危险因素。本研究旨在评估埃塞俄比亚西北部西登比亚Chuahit卫生中心感染和不感染人类免疫缺陷病毒(HIV)的个体中曼氏血吸虫感染的流行程度和强度及其相关危险因素。方法:于2019年3月至4月进行基于机构的横断面研究。采用系统方便的抽样方法，共纳入266名研究对象。采用预测的结构化问卷收集数据。收集单个粪便样本并检查曼氏沙门氏菌卵。采集手指穿刺和静脉血进行HIV-1筛查和病毒载量计数。数据分析采用SPSS version 20。分别采用独立t检验和单因素方差分析比较卵子计数与HIV状态和病毒载量的平均值。p值小于0.05为有统计学意义。结果:总感染率为41个(15.4%)，感染强度为162.24个/ g (EPG)。mansoni的患病率在血清阴性的研究参与者中较高，但差异无统计学意义。在血清阳性的研究参与者中观察到较高的感染强度，病毒载量计数高(1000拷贝/mL)。结论:马氏链球菌感染的流行程度和强度较高。研究参与者的职业被确定为曼氏链球菌感染的潜在危险因素。需要进一步的研究来了解HIV对研究地区曼氏链球菌感染流行率和强度的影响。
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