Insights into Novel Excipients of Self-Emulsifying Drug Delivery Systems and Their Significance: An Updated Review.

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2021-01-01 DOI:10.1615/CritRevTherDrugCarrierSyst.2020034975

Earle Radha Rani, G V Radha

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引用次数: 3

Abstract

Self-emulsifying drug delivery system (SEDDS), a category of lipid-based technology, has gained interest in the recent years for enhancement of solubility and bioavailability of poorly water-soluble drugs. With the progress of research in this field, novel excipients have been developed with enhanced properties. But excipient selection is the key hurdle in the formulation of SEDDS. The objective of this review is to summarize different types of oils, surfactants, co-surfactants which are the key components of liquid SEDDS (L-SEDDS), various carriers utilized in the conversion of L-SEDDS to solid SEDDS (S-SEDDS), their description, properties, grades, and applications in pharmacy. This article provides an overview of solidification techniques to transform L-SEDDS to S-SEDDS which are more stable and have better patience compliance. This review presents numerous literature reports on various excipients used and the discussion on how these excipients affect the final results.

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自乳化给药系统的新型赋形剂及其意义:最新综述。

自乳化给药系统(SEDDS)是一类以脂质为基础的技术，近年来在提高水溶性差药物的溶解度和生物利用度方面得到了广泛的关注。随着这一领域研究的不断深入，新型赋形剂的性能不断提高。但辅料的选择是SEDDS制剂的关键环节。本文综述了液体SEDDS (L-SEDDS)的主要成分油类、表面活性剂、助表面活性剂、L-SEDDS转化为固体SEDDS (S-SEDDS)的各种载体、它们的描述、性质、等级及其在制药领域的应用。本文综述了将L-SEDDS转化为S-SEDDS的凝固技术，使其更稳定，具有更好的耐性依从性。这篇综述提出了大量的文献报告，各种辅料的使用和讨论这些辅料如何影响最终结果。

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来源期刊

Critical Reviews in Therapeutic Drug Carrier Systems 医学-药学

CiteScore

5.50

自引率

18.50%

发文量

审稿时长

>12 weeks

期刊介绍： Therapeutic uses of a variety of drug carrier systems have significant impact on the treatment and potential cure of many chronic diseases, including cancer, diabetes mellitus, psoriasis, parkinsons, Alzheimer, rheumatoid arthritis, HIV infection, infectious diseases, asthma, and drug addiction. Scientific efforts in these areas are multidisciplinary, involving the physical, biological, medical, pharmaceutical, biological materials, and engineering fields. Articles concerning this field appear in a wide variety of journals. With the vast increase in the number of articles and the tendency to fragment science, it becomes increasingly difficult to keep abreast of the literature and to sort out and evaluate the importance and reliability of the data, especially when proprietary considerations are involved. Abstracts and noncritical articles often do not provide a sufficiently reliable basis for proper assessment of a given field without the additional perusal of the original literature. This journal bridges this gap by publishing authoritative, objective, comprehensive multidisciplinary critical review papers with emphasis on formulation and delivery systems. Both invited and contributed articles are subject to peer review.