Perioperative anaphylaxis to chlorhexidine: Crucial role of in-vitro testing.

IF 2.3 4区医学 Q3 ALLERGY Asian Pacific journal of allergy and immunology Pub Date : 2024-03-01 DOI:10.12932/AP-250620-0890

Alessandro Buonomo, Arianna Aruanno, Valter Perilli, Angela Rizzi, Manuela Ferraironi, Eleonora Nucera

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引用次数: 0

Abstract

Background: Chlorhexidine is a synthetic biguanide with a broad antibacterial activity and has become an important cause of perioperative anaphylaxis.

Objective: Reactions due to chlorhexidine allergy are usually IgE-mediated. The aim of this report is to demonstrate utility of laboratory in-vitro testing for diagnosis.

Methods: We report the case of a 36-year old man who experienced severe anaphylaxis during general anesthesia. He underwent skin tests, specific detection of specific IgE to chlorhexidine and basophil activation test (BAT).

Results: Skin tests gave false positive results due to dermographism. So, on the basis of a clinical reaction to chlorhexidine and positive tests for IgE to chlorexidine and BAT, we assessed the diagnosis of chlorhexidine allergy.

Conclusions: Physicians should be aware of the role of chlorhexidine in the etiology of perioperative anaphylaxis. In vitro testing such specific IgE and BAT are useful in patient with suspected chlorexidine allergy and limitation to perform skin tests.

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围手术期对洗必泰的过敏性休克：体外测试的关键作用。

背景：洗必泰是一种具有广泛抗菌活性的合成双胍类药物，已成为围手术期过敏性休克的重要原因：洗必泰是一种合成双胍，具有广泛的抗菌活性，已成为围手术期过敏性休克的重要原因：洗必泰过敏反应通常由 IgE 介导。本报告旨在证明实验室体外检测对诊断的实用性：我们报告了一例在全身麻醉过程中发生严重过敏性休克的 36 岁男性病例。他接受了皮肤测试、洗必泰特异性 IgE 检测和嗜碱性粒细胞活化测试（BAT）：结果：皮肤试验因皮肤显影而出现假阳性结果。因此，根据对洗必泰的临床反应以及氯雷他定特异性 IgE 和嗜碱性粒细胞活化试验（BAT）的阳性检测结果，我们对洗必泰过敏的诊断进行了评估：医生应了解洗必泰在围手术期过敏性休克病因中的作用。特异性 IgE 和 BAT 等体外检测对于怀疑对洗必泰过敏且无法进行皮试的患者非常有用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Pacific journal of allergy and immunology 医学-过敏

CiteScore

12.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747 APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume. APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand. The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.