A unique profile of serum cytokines in type 1 autoimmune pancreatitis and chronic rhinosinusitis.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-06-01 DOI:10.12932/AP-311020-0990

Tomoe Yoshikawa, Kosuke Minaga, Akane Hara, Ikue Sekai, Yasuo Otsuka, Ryutaro Takada, Ken Kamata, Tomohiro Watanabe, Masatoshi Kudo

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Abstract

Background: Type 1 autoimmune pancreatitis (AIP) is a pancreatic manifestation of IgG4-related disease (IgG4-RD). Although AIP and IgG4-RD are characterized by multiple organ involvement including salivary glands, lung, and kidney, co-occurrence of chronic rhinosinusitis (CRS) and AIP/IgG4-RD has been poorly defined.

Objective: We explored molecular mechanism accounting for the co-occurrence of CRS and AIP/IgG4-RD.

Methods: Serum concentrations of IFN-α and IL-33 were measured by enzyme-linked immune-sorbent assay.

Results: We encountered a patient with concurrent type 1 AIP/IgG4-RD and CRS. Induction of remission by prednisolone (PSL) for type 1 AIP/IgG4-RD led to a marked improvement of CRS. Serum cytokine analysis after PSL treatment revealed a marked reduction in serum concentrations of IFN-α and IL-33, both of which are candidate pathogenic cytokines for AIP/IgG4-RD.

Conclusions: Given that IL-33 is shared as one of pathogenic cytokines by type 1 AIP/IgG4-RD and CRS, enhanced IL33 responses may cause concurrent type 1 AIP/IgG4-RD and CRS.

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1 型自身免疫性胰腺炎和慢性鼻炎患者血清细胞因子的独特特征。

背景：1型自身免疫性胰腺炎（AIP）是IgG4相关疾病（IgG4-RD）的胰腺表现。虽然AIP和IgG4-RD的特点是多器官受累，包括唾液腺、肺和肾，但慢性鼻炎（CRS）和AIP/IgG4-RD的并发症尚未明确：我们探讨了CRS和AIP/IgG4-RD并发的分子机制：用酶联免疫吸附法测定血清中IFN-α和IL-33的浓度：我们遇到了一名同时患有1型AIP/IgG4-RD和CRS的患者。通过泼尼松龙（PSL）诱导1型AIP/IgG4-RD缓解，CRS明显好转。PSL治疗后的血清细胞因子分析显示，IFN-α和IL-33的血清浓度明显降低，而这两种细胞因子都是AIP/IgG4-RD的候选致病细胞因子：结论：鉴于IL-33是1型AIP/IgG4-RD和CRS的共同致病细胞因子之一，IL33反应增强可能会导致1型AIP/IgG4-RD和CRS并发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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