{"title":"BRD treatment failure: clinical and pathologic considerations.","authors":"T L Ollivett","doi":"10.1017/S1466252320000328","DOIUrl":null,"url":null,"abstract":"<p><p>In cattle treated for respiratory disease, resolution of clinical signs has been the mainstay of determining treatment response and treatment efficacy. Through the use of calf lung ultrasound, we have found that pneumonia can persist or recur in the face of antibiotic therapy, despite improved clinical signs, leading to greater risk of clinical disease and more antibiotic use in the future. This review will discuss the pros and cons of using clinical signs to define resolution of disease and discuss how to implement lung ultrasound to improve our ability to accurately measure the impact of antibiotic therapy in cattle with respiratory disease.</p>","PeriodicalId":51313,"journal":{"name":"Animal Health Research Reviews","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1466252320000328","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Animal Health Research Reviews","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1017/S1466252320000328","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 5
Abstract
In cattle treated for respiratory disease, resolution of clinical signs has been the mainstay of determining treatment response and treatment efficacy. Through the use of calf lung ultrasound, we have found that pneumonia can persist or recur in the face of antibiotic therapy, despite improved clinical signs, leading to greater risk of clinical disease and more antibiotic use in the future. This review will discuss the pros and cons of using clinical signs to define resolution of disease and discuss how to implement lung ultrasound to improve our ability to accurately measure the impact of antibiotic therapy in cattle with respiratory disease.
期刊介绍:
Animal Health Research Reviews provides an international forum for the publication of reviews and commentaries on all aspects of animal health. Papers include in-depth analyses and broader overviews of all facets of health and science in both domestic and wild animals. Major subject areas include physiology and pharmacology, parasitology, bacteriology, food and environmental safety, epidemiology and virology. The journal is of interest to researchers involved in animal health, parasitologists, food safety experts and academics interested in all aspects of animal production and welfare.