Rare nocardiosis in danish patient with diabetes.

IF 1.8 Q3 RESPIRATORY SYSTEM European Clinical Respiratory Journal Pub Date : 2021-02-24 DOI:10.1080/20018525.2021.1882030
Cecilie Norup Thomsen, Søren Sperling, Joan Fledelius, Pia Holland Gjørup
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引用次数: 1

Abstract

We herein report a rare case that describes and visualizes nocardiosis in a patient with diabetes. The patient presented with recurring fever, gout, leg pain, frailty and muscular pain through nine months, before a core needle biopsi, from an abscess in the abdominal musculature, revealed Nocardia Paucivorans. A PET-CT-scan showed multiple muscular FDG-positive sites. Furthermore, he experienced serious side effects to Sulfametoxazole and Trimethoprim, the antibiotic of choice for this type of infection. He was then switched to Moxifloxacin and Ampicillin. Nocardia often presents as opportunistic infections, typically in patients with severe immunodeficiencies, such as HIV, use of high-dose corticosteroids, hematologic malignancies or immunosuppression following organ transplantation. This case illustrates how a patient with only relative immunodeficiency gets rare nocardiosis. Our sparse knowledge on clinical presentation is based on case-reports and treatment is empirical. Hence, a better understanding of the clinical presentation and treatment is important. Especially given the prospect, that the health care system faces a greater load of patients with diabetes and other immunodeficiencies in the future.

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丹麦糖尿病患者罕见诺卡菌病。
我们在此报告一个罕见的情况下,描述和可视化诺卡病患者的糖尿病。患者表现为反复发热、痛风、腿部疼痛、虚弱和肌肉疼痛,持续了9个月,然后在腹部肌肉组织的脓肿处进行了核心针活检,发现了诺卡菌。pet - ct扫描显示多个肌肉fdg阳性部位。此外,他还经历了磺胺甲恶唑和甲氧苄啶的严重副作用,这是治疗这种感染的首选抗生素。随后改用莫西沙星和氨苄西林。诺卡菌通常表现为机会性感染,通常发生在患有严重免疫缺陷的患者中,如艾滋病毒、使用大剂量皮质类固醇、血液恶性肿瘤或器官移植后免疫抑制。这个病例说明了一个只有相对免疫缺陷的病人是如何得到罕见的诺卡病的。我们对临床表现的稀疏知识是基于病例报告和治疗经验。因此,更好地了解临床表现和治疗是很重要的。特别是考虑到未来的前景,医疗保健系统将面临更大的糖尿病和其他免疫缺陷患者的负担。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
15
审稿时长
16 weeks
期刊最新文献
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