Kristi L Helke, David K Meyerholz, Amanda P Beck, Eric R Burrough, Rachel J Derscheid, Christiane Löhr, Elizabeth F McInnes, Cheryl L Scudamore, Cory F Brayton
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引用次数: 4
Abstract
Animal models provide a valuable tool and resource for biomedical researchers as they investigate biological processes, disease pathogenesis, novel therapies, and toxicologic studies. Interpretation of animal model data requires knowledge not only of the processes/diseases being studied but also awareness of spontaneous conditions and background lesions in the model that can influence or even confound the study results. Species, breed/stock, sex, age, anatomy, physiology, diseases (noninfectious and infectious), and neoplastic processes are model features that can impact the results as well as study interpretation. Here, we review these features in several common laboratory animal species, including ferret, dog (beagle), pig, sheep, and goats.
期刊介绍：
The ILAR Journal is the peer-reviewed, theme-oriented publication of the Institute for Laboratory Animal Research (ILAR), which provides timely information for all who study, use, care for, and oversee the use of animals in research. The journal publishes original articles that review research on animals either as direct subjects or as surrogates for humans. According to policy, any previously unpublished animal research reported in the ILAR Journal will have been conducted according to the scientific, technical, and humanely appropriate guidelines current at the time the research was conducted in accordance with the Guide for the Care and Use of Laboratory Animals or other guidance provided by taxonomically-oriented professional societies (e.g., American Society of Mammalogy) as referenced in the Guide.
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