Nasopharyngeal Carcinoma Ex Pleomorphic Adenoma: Case Report and Comprehensive Literature Review.

IF 0.4 Q4 OTORHINOLARYNGOLOGY Case Reports in Otolaryngology Pub Date : 2021-02-26 eCollection Date: 2021-01-01 DOI:10.1155/2021/8892280
Ellen L Tokarz, Adian A Ong, Mark S Burke
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Abstract

Carcinoma ex pleomorphic adenoma (CXPA) is an epithelial malignancy that transforms from benign pleomorphic adenomas (PA) at a rate of 1.5% after 5 years and 10% after 15 years. The average age of reported nasopharyngeal CXPA is 56.7 years. However, the present case describes a 19-year-old making this case exceptionally rare. Standard treatment is wide local excision with adjuvant treatment. We report the demographics, presentation, treatment, and outcomes of 8 cases of nasopharyngeal CXPA. While surgical excision is the mainstay of treatment, negative margins can be difficult to obtain at the skull base, and we report a recurrence rate of 50% in nasopharyngeal primaries. Due to the aggressive nature of the disease and high rate of recurrence, the majority of patients in our review received adjuvant radiation with some receiving adjuvant chemotherapy in addition.

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鼻咽癌多形性腺瘤1例报告及综合文献复习。
癌前多形性腺瘤(CXPA)是一种由良性多形性腺瘤(PA)转变而来的上皮性恶性肿瘤,5年后发病率为1.5%,15年后发病率为10%。报告的鼻咽部CXPA的平均年龄为56.7岁。然而,本病例描述了一名19岁的患者,使得这种情况非常罕见。标准治疗是局部广泛切除配合辅助治疗。我们报告8例鼻咽炎的人口统计学、表现、治疗和结果。虽然手术切除是主要的治疗方法,但在颅底很难获得阴性切缘,我们报告鼻咽部原发的复发率为50%。由于疾病的侵袭性和高复发率,在我们的综述中,大多数患者接受辅助放疗,一些患者还接受辅助化疗。
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来源期刊
Case Reports in Otolaryngology
Case Reports in Otolaryngology OTORHINOLARYNGOLOGY-
自引率
0.00%
发文量
20
审稿时长
13 weeks
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