Prevalence of pulmonary mycoses in smear-negative patients with suspected tuberculosis in the Brazilian Amazon

IF 1.5 4区生物学 Q4 MYCOLOGY Revista Iberoamericana De Micologia Pub Date : 2021-07-01 DOI:10.1016/j.riam.2020.12.004

Joycenea da Silva Matsuda , Bodo Wanke , Antonio Alcirley da Silva Balieiro , Carla Silvana da Silva Santos , Regia Cristina dos Santos Cavalcante , Mauro de Medeiros Muniz , Daiana Rodrigues Torres , Silviane Bezerra Pinheiro , Hagen Frickmann , João Vicente Braga Souza , Flor Ernestina Martinez-Espinosa

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引用次数: 6

Abstract

Background

Pulmonary mycoses resemble clinically and radiologically chronic pulmonary tuberculosis. Studies describing the prevalence, etiology and clinical features of pulmonary mycosis are of crucial importance in the Brazilian Amazon.

Aims

To estimate the frequency of pulmonary mycoses in smear-negative tuberculosis patients; to describe their demographic, epidemiological, and clinical characteristics; and to evaluate diagnostic methods.

Methods

A cross-sectional study was conducted at two tuberculosis reference institutions in Amazonas, Brazil. We included 213 patients and collected clinical data, blood and induced sputum to perform serological, direct microscopy, microbiologic culture and PCR-based assays to identify infections caused by Aspergillus fumigatus, Paracoccidioides brasiliensis, Histoplasma capsulatum, Cryptococcus, and HIV. Chest computed tomography was also performed.

Results

Pulmonary mycoses were diagnosed in 7% (15/213) of the cases, comprising ten aspergillosis cases, three cases of paracoccidioidomycosis and one case each of histoplasmosis and cryptococcosis. Among the patients with pulmonary mycoses, 86.7% were former tuberculosis patients. The most significant clinical characteristics associated with pulmonary mycoses were cavity-shaped lung injuries, prolonged chronic cough and hemoptysis.

Conclusions

Our study confirmed the high prevalence of pulmonary mycoses in smear-negative tuberculosis patients in the Brazilian Amazon.

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巴西亚马逊地区涂片阴性疑似肺结核患者中肺真菌病的患病率

背景:肺真菌病在临床和放射学上与慢性肺结核相似。研究描述的患病率，病因学和临床特征的肺真菌病是至关重要的巴西亚马逊地区。目的了解痰检阴性肺结核患者肺真菌病的发病情况;描述其人口学、流行病学和临床特征;并评估诊断方法。方法在巴西亚马逊地区的两家结核病参考机构进行横断面研究。我们收集了213例患者的临床资料、血液和诱导痰，进行血清学、直接镜检、微生物培养和基于pcr的检测，以鉴定烟曲霉、巴西副球虫、荚膜组织浆体、隐球菌和HIV引起的感染。同时进行胸部计算机断层扫描。结果肺部真菌病占7%(15/213)，其中曲霉病10例，副球孢子菌病3例，组织浆菌病和隐球菌病各1例。肺真菌病患者中，86.7%为原结核患者。与肺真菌病相关的最显著临床特征是空腔型肺损伤，长时间慢性咳嗽和咯血。结论我们的研究证实了巴西亚马逊地区涂片阴性肺结核患者中肺真菌病的高患病率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Iberoamericana De Micologia MYCOLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

81 days

期刊介绍： Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.