An approach to the evaluation of the potency of cannabis resin in Madrid: A health hazard?

IF 2.2 4区 医学 Q3 SUBSTANCE ABUSE Adicciones Pub Date : 2023-09-01 DOI:10.20882/adicciones.1630
Inmaculada Santos-Álvarez, Pilar Pérez-Lloret, Juncal González-Soriano, Manuel Pérez-Moreno
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引用次数: 3

Abstract

The present study investigates the concentration of Delta (9)-tetrahidrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) in 60 samples of cannabis resin acquired on the streets of Madrid region and its potential danger to consumers' health. Additionally, we study the possible correlation between the potency of samples and their organoleptic characteristics. The analysis of cannabinoids was carried out using a high performance liquid chromatography (RP-HPLC-UV). To classify samples, a strength scale based on THC content was established. THC content in 76.7% of the samples was higher than 15%. This potency allows these samples to be classified as Schedule I or drugs with "unacceptable risk" for human health. THC content in 36.7% of the samples was 28.8% on average, which means very high potency. The mean CBD content was 5%, while the correlation between the CBD/THC ratio and potency was negative. The mean content of CBN was 1.74% and the CBN/THC ratio also showed a negative correlation in respect to potency. When investigating the possible correlation between sample potency and organoleptic characteristics, those samples which simultaneously presented sticky texture, high elasticity and light brown colour had very high potency, with an average THC content of 28.7%. Our study shows that the THC content of most of the cannabis that can be purchased in Madrid region is over 15% and poses a health hazard. Additionally, we demonstrate for the first time that only those samples with very high potency can be directly associated with certain organoleptic characteristics.

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马德里大麻树脂效力评估方法:健康危害?
本研究调查了在马德里地区街头采集的60份大麻树脂样本中四氢大麻酚(THC)、大麻二酚(CBD)和大麻酚(CBN)的浓度及其对消费者健康的潜在危险。此外,我们还研究了样品的效力与其感官特征之间的可能相关性。大麻素的分析使用高效液相色谱法(RP-HPLC-UV)进行。为了对样品进行分类,建立了基于四氢大麻酚含量的强度等级。76.7%的样品中THC含量高于15%。这种效力使这些样本可以被归类为附表一或对人类健康具有“不可接受风险”的药物。36.7%的样品中THC含量平均为28.8%,这意味着非常高的效力。平均CBD含量为5%,而CBD/THC比率与效力之间的相关性为负。CBN的平均含量为1.74%,CBN/THC比率也显示出与效力呈负相关。在研究样品效力和感官特征之间的可能相关性时,那些同时呈现粘性质地、高弹性和浅棕色的样品具有非常高的效力,平均四氢大麻酚含量为28.7%。我们的研究表明,在马德里地区可以买到的大多数大麻的四氢大麻醚含量超过15%,对健康构成危害。此外,我们首次证明,只有那些具有非常高效力的样品才能与某些感官特征直接相关。
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来源期刊
Adicciones
Adicciones SUBSTANCE ABUSE-
CiteScore
4.00
自引率
10.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: Adicciones publica artículos originales sobre el tratamiento, la prevención, estudios básicos y descriptivos en el campo de las adicciones, como son las drogas ilegales, el alcohol, el tabaco o cualquier otra adicción, procedentes de distintas disciplinas (medicina, psicología, investigación básica, investigación social, etc.). Todos los artículos son seleccionados después de pasar un proceso de revisión anónimo hecho por expertos en ese tema.
期刊最新文献
Substitution of higher-strength beers with zero-alcohol beers: Interrupted time series analyses of Spanish household purchase data, 2017-2022. Cannabis use in adult population in Galicia: Prevalence and associated characteristics. Emergency care carried out during the pandemic due to substance abuse in a Spanish province. Training mental health residents in tobacco and alcohol: Relationship with their clinical intervention. Problematic Internet Use among adolescents: Spanish validation of the Compulsive Internet Use Scale (CIUS).
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