Vitamin D Status: Can It Affect the Risk of Infection and the Severity of COVID-19 Symptoms?

IF 3.6 Q2 INFECTIOUS DISEASES Current Tropical Medicine Reports Pub Date : 2021-01-01 Epub Date: 2021-03-31 DOI:10.1007/s40475-021-00236-3

Nicole Paiz, Paula Alonso, Ana Luisa Portillo

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Abstract

Purpose of review: In the midst of the COVID-19 pandemic, several academic studies have emerged that explore the importance of vitamin D in the development of the SARS-CoV2 infection. The basis of this interest comes from the established effect vitamin D status has on other acute respiratory infections, such as influenza. This article aims to determine the role and effect of vitamin D serum concentration in the prevalence and severity of COVID-19.

Recent findings: Several observational studies have demonstrated that suboptimal levels of vitamin D serum concentrations can significantly increase the risk of developing COVID-19 and lead to a more severe symptomatology. One study suggests, however, that supplementation of vitamin D could potentially increase the incidence of mortality in COVID-19 patients.

Summary: Vitamin D status could have an influential role in the development and progression of SARS-CoV2 infection. Further studies are warranted to understand fully the veracity and the extent of this association.

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维生素 D 状态：它能影响感染风险和 COVID-19 症状的严重程度吗？

综述目的：在 COVID-19 大流行期间，有几项学术研究探讨了维生素 D 在 SARS-CoV2 感染发展过程中的重要性。这种兴趣的基础来自于维生素 D 状态对其他急性呼吸道感染（如流感）的既定影响。本文旨在确定维生素 D 血清浓度在 COVID-19 感染率和严重程度中的作用和影响：多项观察性研究表明，维生素 D 血清浓度低于理想水平会显著增加 COVID-19 的发病风险，并导致更严重的症状。然而，一项研究表明，补充维生素 D 有可能增加 COVID-19 患者的死亡率。总结：维生素 D 状态可能对 SARS-CoV2 感染的发生和发展有影响。要充分了解这种关联的真实性和程度，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Tropical Medicine Reports Medicine-Infectious Diseases

CiteScore

9.30

自引率

1.90%

发文量

期刊介绍： Current Tropical Medicine Reports provides expert views on recent advances in the field of tropical medicine in a clear and readable form. This journal offers reviews by domestic and international contributors that highlight the most important, recent papers and findings related to this specific field. We accomplish this by appointing renowned leaders in major tropical medicine subject areas to select topics addressing virology, bacteriology, parasitology, entomology, immunology, cell and molecular biology, epidemiology, ecology, behavioral science and clinical medicine for review by experts who assess the latest developments and highlight significant papers published over the last few years on their topics. These review articles also stress recently published papers of importance in the references, which are accompanied by annotations explaining their importance. In addition to these Section Editors, our international Editorial Board ensures our journal upholds its standards.