Relationship between matrix metalloproteinase-9 and some clinicopathological prognostic factors of breast carcinoma.

IF 1.4 Q4 IMMUNOLOGY American journal of clinical and experimental immunology Pub Date : 2021-02-15 eCollection Date: 2021-01-01
Fereshteh Mohammadizadeh, Mahsa Bagherian-Dehkordia
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Abstract

Background: Matrix metalloproteinase-9 (MMP-9), an enzyme with major role in remodeling of extracellular matrix, has been the focus of attention in some previous studies in the field of breast cancer. In the current study the relationship between matrix metalloproteinase-9 and some clinicopathological factors of breast carcinoma has also been evaluated.

Methods: Formalin-fixed and paraffin-embedded tissue specimens from three groups including 40 invasive breast carcinoma (tumor group) and their adjacent normal tissue (tumor control), as well as 40 normal mammoplasty specimens (normal control) were studied. The samples were from the pathology archive of Alzahra Hospital, Isfahan, Iran, from 2016 to 2018. The status of intraepithelial MMP-9 were studied and compared in these three groups using immunohistochemistry.

Results: The extent of intraepithelial MMP-9 immunostaining in all positive specimens was 100%. The results of intraepithelial MMP-9 staining intensity was as follow: 12.5% strong, 27.5% moderate, 27.5% mild, and 32.5% negative in tumor group; 17.5% strong, 22.5% moderate, 32.5% mild, and 27.5% negative in tumor control group; and 10% strong, 40% moderate, 27.5% mild, and 22.5% negative in normal control group. Intraepithelial MMP-9 immunostaining intensity showed significant difference between tumor and tumor control groups (P<0.001). Intraepithelial MMP-9 immunostaining intensity showed no significant difference between tumor and normal control groups, and between tumor control and normal control groups (P>0.05). No significant relationship was seen between intraepithelial MMP-9 immunostaining intensity and age, tumor size, tumor grade, and lymph node status in tumor group (P>0.05).

Conclusion: Intraepithelial MMP-9 expression increases in some breast carcinomas. Normal breast tissue adjacent to carcinoma does not show such increase. However, intraepithelial MMP-9 expression in breast carcinoma does not show any significant relationship with age, tumor size, tumor grade, and lymph node status.

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基质金属蛋白酶-9与乳腺癌临床病理预后的关系。
背景:基质金属蛋白酶-9 (Matrix metalloproteinase-9, MMP-9)是一种参与细胞外基质重塑的重要酶,是乳腺癌研究的热点。在目前的研究中,基质金属蛋白酶-9与乳腺癌的一些临床病理因素的关系也得到了评价。方法:选取40例浸润性乳腺癌(肿瘤组)及其邻近正常组织(肿瘤对照组)和40例正常乳房成形术标本(正常对照组)进行福尔马林固定和石蜡包埋组织标本的研究。样本来自伊朗伊斯法罕Alzahra医院2016年至2018年的病理档案。利用免疫组织化学方法研究并比较三组上皮内MMP-9的状态。结果:所有阳性标本上皮内MMP-9免疫染色率均为100%。上皮内MMP-9染色强度:肿瘤组为12.5%强、27.5%中度、27.5%轻度、32.5%阴性;肿瘤对照组17.5%为强、22.5%为中度、32.5%为轻度、27.5%为阴性;正常对照组为强10%,中度40%,轻度27.5%,阴性22.5%。肿瘤组与肿瘤对照组间上皮内MMP-9免疫染色强度差异有统计学意义(P0.05)。肿瘤组患者上皮内MMP-9免疫染色强度与年龄、肿瘤大小、肿瘤分级、淋巴结状况无显著相关性(P>0.05)。结论:上皮内MMP-9表达在部分乳腺癌中升高。癌旁的正常乳腺组织没有这种增加。然而,上皮内MMP-9在乳腺癌中的表达与年龄、肿瘤大小、肿瘤分级和淋巴结状态没有任何显著关系。
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