Organoid biobanks as a new tool for pre-clinical validation of candidate drug efficacy and safety.

International journal of physiology, pathophysiology and pharmacology Pub Date : 2021-02-15 eCollection Date: 2021-01-01
Gerardo Botti, Maurizio Di Bonito, Monica Cantile
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Abstract

The growing need for personalized medicine for cancer patients has enhanced and optimized the production of living tumor organoids that have become optimal preclinical models for the discovery and screening of anticancer drugs. The systematic collection and storage of tumor organoids through the establishment of dedicated biobanks will represent a fundamental tool for cancer research and clinical trials.

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类器官生物库作为候选药物有效性和安全性临床前验证的新工具。
随着癌症患者对个性化医疗需求的不断增长,活体肿瘤类器官的生产得到了加强和优化,已成为发现和筛选抗癌药物的最佳临床前模型。通过建立专门的生物银行系统地收集和储存肿瘤类器官将成为癌症研究和临床试验的基本工具。
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