Vaccines against antimicrobial resistance: a promising escape route for multidrug resistance.

IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pharmaceutical patent analyst Pub Date : 2021-03-01 Epub Date: 2021-04-08 DOI:10.4155/ppa-2020-0022
Absar Talat, Asad U Khan
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引用次数: 1

Abstract

Antibiotic resistance has become a global health problem requiring urgent intervention. The pace of development and frequency of transmission of antimicrobial resistance have tremendously surpassed the number of antibiotics developed in the past few decades. Emergence and transmission of multidrug-resistant genes, for example, mcr-1 and mcr-5.3, against the last resort of antibiotics has challenged the treatment options. Vaccination is a promising approach with no instance of antimicrobial resistance generation or transmission reported so far. The time required for developing a vaccine, extensive pre- and post-licensure studies and the financial constraints for the R&D has hampered vaccine development over the past few decades. Vaccine can prove to be an effective future strategy for combating antimicrobial resistance.

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抗微生物药物耐药性疫苗:一种有希望的多药耐药性逃避途径。
抗生素耐药性已成为一个需要紧急干预的全球卫生问题。抗生素耐药性的发展速度和传播频率大大超过了过去几十年开发的抗生素数量。耐多药基因的出现和传播,例如mcr-1和mcr-5.3,对抗生素的最后手段提出了挑战。疫苗接种是一种很有希望的方法,迄今没有报告产生或传播抗微生物药物耐药性的实例。在过去几十年中,开发疫苗所需的时间、广泛的许可前和许可后研究以及研发的资金限制阻碍了疫苗的开发。疫苗可被证明是未来对抗抗菌素耐药性的有效战略。
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来源期刊
Pharmaceutical patent analyst
Pharmaceutical patent analyst PHARMACOLOGY & PHARMACY-
CiteScore
1.80
自引率
0.00%
发文量
22
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