The interplay of membrane cholesterol and substrate on vascular smooth muscle biomechanics.

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology Current topics in membranes Pub Date : 2020-01-01 Epub Date: 2020-09-28 DOI:10.1016/bs.ctm.2020.08.003
Hanna J Sanyour, Alex P Rickel, Zhongkui Hong
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Abstract

Cardiovascular disease (CVD) remains the primary cause of death worldwide. Specifically, atherosclerosis is a CVD characterized as a slow progressing chronic inflammatory disease. During atherosclerosis, vascular walls accumulate cholesterol and cause fatty streak formation. The progressive changes in vascular wall stiffness exert alternating mechanical cues on vascular smooth muscle cells (VSMCs). The detachment of VSMCs in the media layer of the vessel and migration toward the intima is a critical step in atherosclerosis. VSMC phenotypic switching is a complicated process that modifies VSMC structure and biomechanical function. These changes affect the expression and function of cell adhesion molecules, thus impacting VSMC migration. Accumulating evidence has shown cholesterol is capable of regulating cellular migration, proliferation, and spreading. However, the interaction and coordinated effects of both cellular cholesterol and the extracellular matrix (ECM) stiffness/composition on VSMC biomechanics remains to be elucidated.

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膜胆固醇和基质对血管平滑肌生物力学的相互作用
心血管疾病(CVD)仍然是全球死亡的主要原因。具体来说,动脉粥样硬化是一种心血管疾病,其特点是进展缓慢的慢性炎症性疾病。在动脉粥样硬化过程中,血管壁会积聚胆固醇,导致脂肪条纹形成。血管壁硬度的逐渐变化对血管平滑肌细胞(VSMC)产生交替的机械刺激。血管介质层中的 VSMC 脱离并向内膜迁移是动脉粥样硬化的关键步骤。VSMC 表型转换是一个复杂的过程,它改变了 VSMC 的结构和生物力学功能。这些变化会影响细胞粘附分子的表达和功能,从而影响 VSMC 的迁移。越来越多的证据表明,胆固醇能够调节细胞的迁移、增殖和扩散。然而,细胞胆固醇和细胞外基质(ECM)硬度/构成对 VSMC 生物力学的相互作用和协调效应仍有待阐明。
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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
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