A comparision of the hemostatic effects of notoginseng and yun nan bai yao to placebo control.

Journal of herbal pharmacotherapy Pub Date : 2005-01-01

Chengde Fan, Jessica Song, C Michael White

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Abstract

Introduction: We previously demonstrated the hemostatic effects of notoginseng using a rat bleeding model. Yun-Nan-Bai-Yao is a proprietary product for external use in China to treat bleeding but the hemostatic effects have not been proven. This study was conducted to compare the hemostatic effects of notoginseng to that of Yun-Nan- Bai-Yao and placebo control.

Methods: Rats (n = 37) were randomized into 3 groups and their tails were transected 5mm from the tip in this blinded investigation. Group 1 received placebo (wheat flour, n = 17), group 2 received notoginseng (n = 10) and group 3 received the Yun-Nan-Bai-Yao (n = 10). The total bleeding time was determined and compared among groups.

Results: Beeding time in minutes was 29.7% and 22.3% lower in the notoginseng and Yun-Nan-Bai-Yao groups than the placebo group (p < 0.001 and p < 0.001, respectively). No significant difference was found between the two active groups (p = 0.418).

Conclusions: When applied externally, both notoginseng and Yun-Nan-Bai-Yao provide appreciable hemostatic effects compared to placebo.

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三七与白云药与安慰剂对照止血效果的比较。

我们之前用大鼠出血模型证明了三七的止血作用。云南白药是中国外用治疗出血的专有产品，但其止血作用尚未得到证实。本研究比较三七与云南白药及安慰剂的止血作用。方法:采用盲法，将37只大鼠随机分为3组，取尾距尾尖5mm处截尾。组1给予安慰剂(小麦粉，n = 17)，组2给予三七(n = 10)，组3给予云南白药(n = 10)。测定两组患者总出血时间并进行比较。结果:三七组和云南白药组的尿时间(min)比安慰剂组分别缩短29.7%和22.3% (p < 0.001和p < 0.001)。两组间无显著性差异(p = 0.418)。结论:与安慰剂相比，三七和云南白药外用均具有明显的止血作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of herbal pharmacotherapy

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