Lung deposition of mannitol powder aerosol in healthy subjects.

William Glover, Hak-Kim Chan, Stefan Eberl, Evangelia Daviskas, Sandra Anderson
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引用次数: 30

Abstract

Mannitol as a dry powder aerosol is used for bronchoprovocation testing and to enhance mucus clearance in people with excessive airway secretions. The dose and distribution of the deposited aerosol in the lung was investigated using fast single photon emission tomography (SPECT) imaging. Mannitol powder (3 microm particle size) was produced by spray drying and radiolabeled with (99m)Tc-DTPA. Approximately 60 mg of radiolabeled mannitol (containing 52-68 MBq of (99m)Tc-DTPA) was administered to 10 healthy subjects using the Inhalator dry powder inhaler (DPI), and SPECT images (1 min each) were collected. Thirteen percent to 31% of the dose of mannitol loaded in the inhaler deposited in the lungs and the deposited dose correlated positively with the peak inhalation air flow. The regional aerosol lung distribution, as expressed by the penetration index (i.e., ratio of peripheral to central deposition in the lung) varied from 0.31 to 0.88, which however showed no dependency on any flow parameters. The variation in response to the same dose of mannitol within the asthmatic population may in part be explained by these findings.

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甘露醇粉末气雾剂在健康人肺中的沉积。
甘露醇作为干粉气雾剂用于支气管刺激试验和增强呼吸道分泌物过多的人的粘液清除。采用快速单光子发射断层扫描(SPECT)技术研究了沉积在肺中的气溶胶的剂量和分布。采用喷雾干燥法制备甘露醇粉末(粒径为3微米),并用(99m)Tc-DTPA进行放射性标记。使用吸入器干粉吸入器(DPI)给10名健康受试者注射约60 mg放射性标记甘露醇(含有52-68 MBq的(99m)Tc-DTPA),并收集SPECT图像(每张1分钟)。吸入器中装载的甘露醇剂量的13%至31%在肺部沉积,沉积剂量与吸入气流峰值呈正相关。气溶胶肺的区域分布,以穿透指数(即肺中周围与中心沉积的比值)表示,变化范围为0.31 ~ 0.88,但不依赖于任何流动参数。哮喘人群对相同剂量甘露醇反应的差异可能部分解释了这些发现。
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