Comparative drug effects: the case of GERD therapies.

Albert I Wertheimer, James M Wilson
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Abstract

The results of clinical trials and approved Food and Drug Administration Drug Applications inform decision makers that a drug was effective in its labeled indications without causing unacceptable side effects. But purchasers for large medical organizations and members of health insurer or managed care organizations need relative effectiveness data to enable them to select the product from among the four, six, or ten competing alternative drug products available in that family. Retrospective studies are capable of providing this data after about a year of use by utilizing a database containing a large number of patients. An alternative means of determining this was explored using a new technique from a nationwide patient satisfaction study. Using GERD as an example, the authors were able to determine differences in patient satisfaction between proton pump inhibitors (PPIs), H(2) antagonists, and antacids, and even within the PPI category, down to individual products. The piloted method is rapid and inexpensive and can be an alternative for clinicians developing disease management protocols for specific conditions.

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药物疗效比较:反流胃食管反流治疗病例。
临床试验的结果和食品和药物管理局批准的药物申请告知决策者,一种药物在其标签适应症中是有效的,不会产生不可接受的副作用。但是大型医疗机构的购买者和健康保险公司或管理式医疗机构的成员需要相对的有效性数据,以使他们能够从该家族中可用的四种、六种或十种相互竞争的替代药物中选择产品。通过利用包含大量患者的数据库,回顾性研究能够在大约一年的使用后提供这些数据。另一种方法是利用一项来自全国患者满意度研究的新技术来确定这一点。以胃食管反流为例,作者能够确定质子泵抑制剂(PPIs)、H(2)拮抗剂和抗酸剂之间的患者满意度差异,甚至在PPI类别内,直至单个产品。该试验方法快速且价格低廉,可作为临床医生针对特定情况制定疾病管理方案的替代方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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